{"id":"W2613610978","doi":"10.1161/atvb.33.suppl_1.a452","title":"Abstract 452: Detailed Characterization of the Role of the Epidermal Growth Factor Precursor Homology Domain A of the Low-density Lipoprotein Receptor in Proprotein Convertase Subtilisin/kexin-type 9 Binding","year":2013,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Proprotein convertase; Kexin; LDL receptor; PCSK9; Epidermal growth factor; Subtilisin; Endosome; Biochemistry; Endocytosis; Biology; Receptor; Binding domain; Heparin-binding EGF-like growth factor; Cell biology; Chemistry; Binding site; Molecular biology; Lipoprotein; Cholesterol; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225432,0.0004491532,0.0002014601,0.0001921509,0.0002071526,0.0002234536,0.0003031777,0.0003239901,0.002858837],"category_scores_gemma":[0.0001241678,0.0001313701,0.0004697143,0.0002326828,0.0001241953,0.0002213377,0.0001629205,0.0003884744,0.001489139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639043,"about_ca_system_score_gemma":0.0002948896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0012724,"about_ca_topic_score_gemma":0.0006111236,"domain_scores_codex":[0.9998713,0.00001557392,0.00001310981,0.00002882684,0.00004594643,0.00002537858],"domain_scores_gemma":[0.9999384,0.00001043002,0.00001159408,0.000006734039,0.00001137532,0.00002155766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009980125,0.00002657677,0.0002394427,0.00002605766,0.000004897285,0.00008022697,0.000007458813,0.0000557228,0.9983725,0.00009389139,0.00007057598,0.0009228034],"study_design_scores_gemma":[0.00002806051,0.0002940232,0.01683659,0.00001242738,0.00003463596,0.0009630992,0.00002503639,0.001276569,0.9668407,0.0001397723,0.01353468,0.00001436598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825165,0.002945701,0.006582691,0.0001967633,0.00009412908,0.00007182719,0.003072073,0.00006471144,0.004455542],"genre_scores_gemma":[0.9585375,0.002823306,0.009370756,0.0002818472,0.0000562565,0.00006877772,0.01730969,0.00007743926,0.01147452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002858837,"threshold_uncertainty_score":0.009563804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403542593630469,"score_gpt":0.2288143899492019,"score_spread":0.2147789640128972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}