{"id":"W2613736820","doi":"10.1016/j.biomaterials.2017.05.019","title":"Selective targeting and therapy of metastatic and multidrug resistant tumors using a long circulating podophyllotoxin nanoparticle","year":2017,"lang":"en","type":"article","venue":"Biomaterials","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Podophyllotoxin; Doxorubicin; Pharmacology; Pharmacokinetics; Cancer research; Medicine; Chemotherapy; Internal medicine; Chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670518,0.0001859061,0.0001592183,0.0001247343,0.0001371277,0.000390481,0.000124744,0.0003128743,0.0003924539],"category_scores_gemma":[0.0001476555,0.0001009265,0.0001178872,0.00007221728,0.0001820296,0.0003640379,0.0002711544,0.0003624885,0.0001222524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003253924,"about_ca_system_score_gemma":0.0002044488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002196709,"about_ca_topic_score_gemma":0.0004989395,"domain_scores_codex":[0.9999367,0.000009702014,0.000003318838,0.00001591207,0.00001529048,0.0000191035],"domain_scores_gemma":[0.999925,0.00001708431,0.00002419968,0.00001002263,0.000008083875,0.00001562561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004012475,0.00002501835,0.0001095527,0.00002119436,0.000002685118,0.00004045577,0.00001726926,0.0001757042,0.9964898,0.0003300658,0.0000447367,0.002703337],"study_design_scores_gemma":[0.00001253825,0.0002360386,0.0006142128,0.000002939737,0.0000112863,0.0001533341,0.0000139675,0.001789595,0.9950017,0.00008537077,0.00207552,0.000003406712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834147,0.001819825,0.01255883,0.0002859694,0.00003996684,0.00002686102,0.00003602438,0.00008761572,0.001730198],"genre_scores_gemma":[0.9943125,0.0005613752,0.002911268,0.00004446891,0.000007690697,0.00001471388,0.00002338466,0.00001364817,0.002110978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003924539,"threshold_uncertainty_score":0.00236094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03750702120202183,"score_gpt":0.3079143598030814,"score_spread":0.2704073386010596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}