{"id":"W2613787007","doi":"10.1016/j.jid.2017.04.026","title":"Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging","year":2017,"lang":"en","type":"review","venue":"Journal of Investigative Dermatology","topic":"Skin Protection and Aging","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Common Fund; NIH Office of the Director; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; National Cancer Institute; Western University; National Human Genome Research Institute; Wellcome Trust; Ophthalmic Research Institute of Australia; Raine Medical Research Foundation; Pfizer Australia; King's College London; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Pfizer; Broad Institute; Curtin University of Technology; National Institute on Drug Abuse; University of Miami; American Health Assistance Foundation","keywords":"Photoaging; Genome-wide association study; Skin cancer; Skin Aging; Biology; Genetic architecture; Allele; Genetics; Penetrance; Single-nucleotide polymorphism; Trait; Family aggregation; Genetic association; Gene; Dermatology; Quantitative trait locus; Phenotype; Genotype; Pathology; Medicine; Cancer; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007760902,0.0003133575,0.002032916,0.0008817276,0.0001267314,0.00005957613,0.0002172438,0.0003969766,0.00005413406],"category_scores_gemma":[0.001595054,0.0002523251,0.0004279332,0.0001863922,0.0001277727,0.0002520823,0.00005298151,0.001124606,0.00002821588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000839968,"about_ca_system_score_gemma":0.0006815771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001682497,"about_ca_topic_score_gemma":0.00002782461,"domain_scores_codex":[0.9973447,0.0006332957,0.001134773,0.0002235476,0.0003711362,0.0002925368],"domain_scores_gemma":[0.99506,0.0005480114,0.003798988,0.000193676,0.0002290564,0.000170253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008805056,0.0003381785,0.1020692,0.01703917,0.003489295,0.004367073,0.00686968,0.00001772165,0.001001367,0.0001545369,0.002548606,0.8620171],"study_design_scores_gemma":[0.001743355,0.00009500905,0.00941273,0.01618945,0.001129595,0.006368256,0.0005939373,0.00001879491,0.003574607,0.001039956,0.9594448,0.0003895226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005736021,0.9904809,0.0001074335,0.001986628,0.0004266863,0.0005932041,0.00000603492,0.00001426542,0.0006488102],"genre_scores_gemma":[0.004029216,0.9936377,0.0008111983,0.0007796406,0.0003130104,0.00004202862,0.0000330217,0.00004475423,0.0003094021],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9568962,"threshold_uncertainty_score":0.9999929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09270766833141979,"score_gpt":0.3651329849392382,"score_spread":0.2724253166078184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}