{"id":"W2613846804","doi":"10.1016/j.bbr.2017.05.021","title":"MeCP2-deficient mice have reduced α4 and α6 nicotinic receptor mRNA and altered behavioral response to nicotinic agonists","year":2017,"lang":"en","type":"article","venue":"Behavioural Brain Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"International Rett Syndrome Foundation","keywords":"Agonist; Nicotine; Nicotinic agonist; MECP2; Nicotinic acetylcholine receptor; Endocrinology; Internal medicine; Open field; Chemistry; Pharmacology; Receptor; Biology; Neuroscience; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268885,0.002182225,0.0009048695,0.002377283,0.0005553812,0.001000183,0.001075612,0.001633341,0.0109965],"category_scores_gemma":[0.0004044261,0.001022979,0.0007057028,0.0005431403,0.001647055,0.0006161483,0.0006726691,0.003300471,0.002054817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007439789,"about_ca_system_score_gemma":0.0004446024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003370304,"about_ca_topic_score_gemma":0.006475875,"domain_scores_codex":[0.9990832,0.00005253472,0.0001017254,0.000252818,0.0003096534,0.0002001468],"domain_scores_gemma":[0.9985561,0.000113781,0.0005787907,0.00008615686,0.0001077479,0.0005574761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002340284,0.00003601261,0.0001725339,0.00002384332,0.0000135106,0.0001603744,0.00002084417,0.00003993866,0.9986376,0.00008647516,0.00006833999,0.000506559],"study_design_scores_gemma":[0.0001240781,0.0002234824,0.01642501,0.00003181611,0.0001190962,0.001637967,0.0002025329,0.0007347339,0.9779515,0.0002774369,0.002241501,0.00003072052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839183,0.0009743605,0.005506203,0.0006395581,0.0002346165,0.00005043241,0.004699816,0.0007200308,0.003256674],"genre_scores_gemma":[0.9529498,0.001124645,0.007444908,0.0004973037,0.00007401519,0.0002282239,0.003449576,0.0008814844,0.03335007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0109965,"threshold_uncertainty_score":0.03678691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09730066051362042,"score_gpt":0.3973690187023717,"score_spread":0.3000683581887513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}