{"id":"W2613896132","doi":"10.1371/journal.pone.0177372","title":"HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Micrococcal nuclease; Chromatin; Biology; Histone H4; Histone H1; Histone acetyltransferase; Nucleosome; Histone code; Histone; Histone H2A; Leishmania donovani; Histone methylation; Molecular biology; Histone octamer; Acetylation; Cell biology; Biochemistry; Genetics; Gene expression; Gene; DNA methylation; Visceral leishmaniasis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600831,0.0003759835,0.0002572825,0.0002162934,0.0001837444,0.0003114642,0.0002483321,0.0002466744,0.001369136],"category_scores_gemma":[0.0001506069,0.0002689904,0.0003112938,0.0001654608,0.0002355532,0.0001328164,0.0003382928,0.0003765158,0.000476174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003486498,"about_ca_system_score_gemma":0.00013439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0012933,"about_ca_topic_score_gemma":0.001833498,"domain_scores_codex":[0.9998198,0.00003195499,0.00001516967,0.00003915421,0.00004081166,0.00005324362],"domain_scores_gemma":[0.9998758,0.00002465325,0.00003216728,0.00001618599,0.00001884498,0.00003232401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004467951,0.00001158408,0.000203072,0.000030839,0.000003437602,0.00004122167,0.000009673317,0.00001987568,0.9993781,0.00002690207,0.00002525992,0.0002052658],"study_design_scores_gemma":[0.00001203588,0.0001737423,0.00888251,0.000005579348,0.00001259856,0.0003246228,0.00004700059,0.0006647105,0.9877324,0.00003538128,0.002102071,0.000007396344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941367,0.002058953,0.00137995,0.0001314126,0.00003853246,0.00001934067,0.0006944551,0.00009371406,0.001447017],"genre_scores_gemma":[0.9935303,0.0004805179,0.0009337136,0.00006439758,0.000007608783,0.00001976929,0.001469015,0.0000271855,0.003467536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369136,"threshold_uncertainty_score":0.004580259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.049961087172211,"score_gpt":0.3027783993937703,"score_spread":0.2528173122215593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}