{"id":"W2613925306","doi":"10.1038/nprot.2017.029","title":"Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs","year":2017,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Biology; Sequencing by hybridization; Genetics; DNA nanoball sequencing; DNA; Single molecule real time sequencing; Genome; Genomic library; DNA sequencing; Homologous recombination; Computational biology; Gene; DNA sequencer; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007042146,0.0006789788,0.0009448563,0.0005287839,0.000505066,0.001518747,0.0007244218,0.0009175963,0.00277503],"category_scores_gemma":[0.001049437,0.000609838,0.0006205077,0.0004886397,0.0004383706,0.0007697939,0.0007957242,0.001621079,0.003996976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004899349,"about_ca_system_score_gemma":0.0008394627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000293,"about_ca_topic_score_gemma":0.004470496,"domain_scores_codex":[0.9995485,0.00003880535,0.00003807994,0.0001905481,0.0001419717,0.0000420839],"domain_scores_gemma":[0.9991209,0.0002815282,0.00009137407,0.0002582795,0.0001508646,0.00009702391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004439064,0.00001068797,0.0003279827,0.0000739773,0.000009571972,0.00004233127,0.00004617908,0.0001611927,0.993553,0.000510083,0.0004410475,0.004779476],"study_design_scores_gemma":[0.00001328026,0.00005772258,0.002103177,0.00001487406,0.00003048783,0.0001947766,0.00005804425,0.006133545,0.9737684,0.001090515,0.01651524,0.00001989941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3693793,0.0024401,0.5897087,0.0006165408,0.0005307297,0.0004109438,0.02048606,0.005656926,0.01077066],"genre_scores_gemma":[0.5269322,0.00296867,0.4163857,0.0007826629,0.000108747,0.0006342666,0.03244228,0.003632428,0.01611312],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00277503,"threshold_uncertainty_score":0.009283423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889711629101098,"score_gpt":0.2809410640258254,"score_spread":0.2620439477348144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}