{"id":"W2614012162","doi":"10.1016/j.jacl.2017.04.071","title":"The APPROACH Study: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Volanesorsen Administered Subcutaneously to Patients with Familial Chylomicronemia Syndrome (FCS)","year":2017,"lang":"en","type":"article","venue":"Journal of clinical lipidology","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Traditional medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007794959,0.0004000921,0.004904247,0.000234507,0.0003693421,0.00008844644,0.0009715097,0.0002678675,0.00003255266],"category_scores_gemma":[0.007148252,0.0002013488,0.0007483885,0.000118867,0.0006632732,0.0001477473,0.000224048,0.0009783392,0.00001407267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002515692,"about_ca_system_score_gemma":0.0005151281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001263445,"about_ca_topic_score_gemma":0.000158939,"domain_scores_codex":[0.9925635,0.001628549,0.003907298,0.000480977,0.0009281085,0.0004915973],"domain_scores_gemma":[0.9901471,0.003270211,0.00389522,0.001259305,0.0008696184,0.0005585212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8599556,0.01720561,0.1166802,0.00002605725,0.002288224,0.0001201257,0.00105179,0.00001392109,0.000008377896,0.00001583463,0.0004731925,0.002161052],"study_design_scores_gemma":[0.9192135,0.02960661,0.04420523,0.00004159297,0.003030277,0.0003868801,0.00237828,0.00002934181,0.000001626576,0.00001808522,0.000890377,0.0001981569],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987166,0.00009990679,0.00007058909,0.0006261165,0.003662645,0.007703112,0.000009841132,0.00001182277,0.0006499514],"genre_scores_gemma":[0.9968587,0.00005793107,0.0003267558,0.0002417223,0.001918403,0.0001194291,0.000005388556,0.00004449421,0.0004271892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07247496,"threshold_uncertainty_score":0.8557642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0645473816067762,"score_gpt":0.3995648640946394,"score_spread":0.3350174824878632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}