{"id":"W2614078609","doi":"10.1089/ars.2016.6855","title":"The Keap1–Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1","year":2017,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Sunnybrook Hospital; Sunnybrook Health Science Centre; University of Calgary; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Mitochondrial fission; DNAJA3; KEAP1; Cell biology; mitochondrial fusion; Mitochondrion; Biology; Gene knockdown; Regulator; MFN2; Oxidative stress; Proteasome; Mitochondrial DNA; Transcription factor; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.000274198,0.0002172495,0.0002047002,0.00001787497,0.001318804,0.0001556401,0.0005379913,0.000200143,0.000006049756],"category_scores_gemma":[0.000700282,0.0001270446,0.0001431963,0.00004020321,0.0004485926,0.00002314522,0.0003557301,0.0001609161,0.000001007335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009314184,"about_ca_system_score_gemma":0.0001041941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006677269,"about_ca_topic_score_gemma":0.00003780956,"domain_scores_codex":[0.9984635,0.0002373266,0.0003621883,0.00042575,0.0002342271,0.0002770565],"domain_scores_gemma":[0.9984955,0.00006093106,0.0004816033,0.000751749,0.0001531256,0.00005708465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009621409,0.00005548719,0.0008356798,0.00002685188,0.00003581692,0.000001198453,0.0001486942,0.000005979633,0.9957886,0.00007918322,0.0001249519,0.0019354],"study_design_scores_gemma":[0.000867356,0.0001756157,0.003203738,0.0002470088,0.00002141132,0.000004823655,0.0002034097,0.00003117586,0.9910548,0.0006425641,0.003363573,0.000184466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968504,0.0006406773,0.0004866336,0.0005553975,0.0005885014,0.000667467,0.0000671838,0.000007466261,0.0001362251],"genre_scores_gemma":[0.9966516,0.0002024369,0.001292631,0.00002648062,0.0005817934,0.00002679663,0.00002522998,0.00002443271,0.001168558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004733758,"threshold_uncertainty_score":0.9999813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242976235835887,"score_gpt":0.2498864155077199,"score_spread":0.237456653149361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}