{"id":"W2614078609","doi":"10.1089/ars.2016.6855","title":"The Keap1–Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1","year":2017,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Sunnybrook Hospital; Sunnybrook Health Science Centre; University of Calgary; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Mitochondrial fission; DNAJA3; KEAP1; Cell biology; mitochondrial fusion; Mitochondrion; Biology; Gene knockdown; Regulator; MFN2; Oxidative stress; Proteasome; Mitochondrial DNA; Transcription factor; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002604784,0.0003468147,0.0003574605,0.0002115543,0.0002262792,0.0002483847,0.0001782001,0.0002533176,0.002074876],"category_scores_gemma":[0.000162253,0.0001093404,0.0003539862,0.0001503185,0.0002186263,0.0003538194,0.0002765803,0.0005455758,0.0003852105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363897,"about_ca_system_score_gemma":0.0001881632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000264902,"about_ca_topic_score_gemma":0.0004163411,"domain_scores_codex":[0.9998273,0.00002607024,0.00002254866,0.00004878329,0.00004327924,0.00003200788],"domain_scores_gemma":[0.9998844,0.00001370167,0.00004439393,0.00001311618,0.00001965386,0.00002476181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001735903,0.00002570067,0.000158956,0.00008044663,0.000009982166,0.00006146812,0.00001261246,0.0000461319,0.9981698,0.00008387893,0.00006829567,0.00110903],"study_design_scores_gemma":[0.00002351839,0.0002456804,0.004801173,0.000009893983,0.00002520645,0.0003563145,0.00003602889,0.0008618516,0.990887,0.00009240196,0.002655484,0.000005497248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846494,0.005283247,0.00725184,0.0004096219,0.00006810183,0.00003842363,0.0005801654,0.0002021566,0.00151717],"genre_scores_gemma":[0.9931813,0.001629322,0.002237178,0.00008743937,0.00001244528,0.00003845845,0.0005444449,0.00001725819,0.002252161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002074876,"threshold_uncertainty_score":0.00694114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242976235835887,"score_gpt":0.2498864155077199,"score_spread":0.237456653149361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}