{"id":"W2614083744","doi":"10.1002/acn3.412","title":"A novel design of a Phase III trial of isradipine in early Parkinson disease (STEADY‐PD III)","year":2017,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Medicine; Parkinson's disease; Ambulatory; Placebo; Cohort; Rating scale; Quality of life (healthcare); Physical therapy; Isradipine; Clinical trial; Disease; Internal medicine; Physical medicine and rehabilitation; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000538862,0.0001363675,0.00079732,0.00010476,0.00004043865,0.000003876371,0.000109403,0.0001310006,0.00003073298],"category_scores_gemma":[0.0003013813,0.0001135067,0.0002464328,0.00005009294,0.0003872312,0.00008548181,0.00001933787,0.0001500847,7.757318e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":2.334114e-7,"about_ca_system_score_gemma":0.0001647914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001032773,"about_ca_topic_score_gemma":0.00001118868,"domain_scores_codex":[0.9981622,0.0001258445,0.0009941881,0.000309777,0.0002438849,0.0001641514],"domain_scores_gemma":[0.9983919,0.0004893269,0.0004840619,0.0002890035,0.000116702,0.000229067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6205024,0.01224088,0.3421362,0.000121554,0.0004210542,0.0001615481,0.00008276541,0.00004262018,0.000635009,0.003384991,0.00002963119,0.02024135],"study_design_scores_gemma":[0.1563876,0.004453992,0.8321253,0.00004958881,0.0001924607,0.000003860437,7.516543e-7,0.001686668,0.000237118,0.00421173,0.0005818807,0.00006906562],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993095,0.0003188614,0.001402682,0.004204321,0.0001253183,0.0005805375,0.0001601687,0.000004935828,0.0001081349],"genre_scores_gemma":[0.9986151,0.0004173301,0.0003715927,0.0004314322,0.0000947893,0.00001931866,0.00002225292,0.00001006971,0.00001815685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4899891,"threshold_uncertainty_score":0.4628669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2012742590211967,"score_gpt":0.4336164611956999,"score_spread":0.2323422021745031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}