{"id":"W2614086487","doi":"10.1158/1538-7445.transcontrol16-a08","title":"Abstract A08: A 5' UTR RNA G-Quadruplex structure affects both the cap-dependent and independent translation of BAG-1, an mRNA involved in colorectal cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Internal ribosome entry site; Five prime untranslated region; Messenger RNA; Untranslated region; Gene isoform; Translational regulation; Translation (biology); Open reading frame; Biology; Eukaryotic translation; Three prime untranslated region; Coding region; Start codon; Ribosome; RNA; Stop codon; Genetics; Molecular biology; Gene; Peptide sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349576,0.0002750055,0.0002121732,0.000167749,0.0001244581,0.0001700985,0.0002116973,0.0004042862,0.00414964],"category_scores_gemma":[0.0001581402,0.000139429,0.0002933189,0.0000688479,0.0002647533,0.000117122,0.0001286992,0.0005524184,0.0007602844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984493,"about_ca_system_score_gemma":0.0001548897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003403247,"about_ca_topic_score_gemma":0.0003748808,"domain_scores_codex":[0.9998307,0.00004636306,0.0000205698,0.00004543286,0.00002611855,0.00003075224],"domain_scores_gemma":[0.9997373,0.00007752338,0.00006915097,0.00002180487,0.00002004539,0.00007425435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005603406,0.00008391195,0.0001336337,0.00003382814,0.000008735298,0.00003330654,0.00000786664,0.0000334106,0.9984359,0.00003630649,0.00006517493,0.0005676824],"study_design_scores_gemma":[0.00009643536,0.002211528,0.005685835,0.000009840835,0.00004380865,0.0001952962,0.00001941602,0.001108431,0.9893538,0.00006265935,0.001203925,0.000009085085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976448,0.0003434436,0.0008653002,0.00008154358,0.00006929026,0.00002056707,0.0004601956,0.0001021181,0.0004126622],"genre_scores_gemma":[0.9965159,0.0001042125,0.0009461461,0.0001476312,0.00002213714,0.00003789943,0.0007445781,0.00004467085,0.001436894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00414964,"threshold_uncertainty_score":0.01388192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05368488310099916,"score_gpt":0.3669599382385744,"score_spread":0.3132750551375753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}