{"id":"W2614088513","doi":"10.1093/neuonc/nox093","title":"Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Topotecan; Medicine; Panobinostat; Decitabine; Pharmacology; Paclitaxel; Vincristine; Combination therapy; Cancer research; PLK1; In vivo; Oncology; Internal medicine; Chemotherapy; Cancer; Cell cycle; Biology; Histone deacetylase; Cyclophosphamide; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135082,0.0002327877,0.0005656474,0.00007452966,0.0003163382,0.00006924228,0.0001950864,0.0001533589,0.0000879156],"category_scores_gemma":[0.001109191,0.0001890305,0.0001467649,0.00003193283,0.0001485053,0.0001097237,0.0001356119,0.0002265243,0.00003655736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118923,"about_ca_system_score_gemma":0.0004222678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007996823,"about_ca_topic_score_gemma":0.0003440366,"domain_scores_codex":[0.9983959,0.0001136977,0.0003876658,0.0005278426,0.0001775171,0.0003973457],"domain_scores_gemma":[0.9979362,0.0007087591,0.0003320957,0.0005348215,0.0001057248,0.0003823573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004672816,0.002699688,0.606319,0.0001132909,0.0004744397,0.0007569975,0.0004411646,0.000004040206,0.09049336,0.0003849786,0.04290494,0.2507353],"study_design_scores_gemma":[0.03987273,0.01136435,0.7273656,0.0001482533,0.001025745,0.000295013,0.00007291618,0.0001380566,0.04971387,0.002874474,0.166681,0.000448005],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645795,0.0002361486,0.00001674935,0.03249041,0.0005263992,0.001482904,0.000045051,0.00003934584,0.0005834971],"genre_scores_gemma":[0.9916391,0.0000565901,0.0003731334,0.007050077,0.0003784443,0.0001123558,0.00005087673,0.00004023419,0.0002991407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2502873,"threshold_uncertainty_score":0.770844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153955396598612,"score_gpt":0.3513405280390305,"score_spread":0.3198009740730444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}