{"id":"W2614088513","doi":"10.1093/neuonc/nox093","title":"Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Topotecan; Medicine; Panobinostat; Decitabine; Pharmacology; Paclitaxel; Vincristine; Combination therapy; Cancer research; PLK1; In vivo; Oncology; Internal medicine; Chemotherapy; Cancer; Cell cycle; Biology; Histone deacetylase; Cyclophosphamide; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397618,0.0005217556,0.0005910993,0.0004871115,0.00017822,0.0004547945,0.0004074012,0.000268011,0.002627664],"category_scores_gemma":[0.000167733,0.0001269343,0.0004031165,0.0003647733,0.0001794814,0.0002133948,0.0001749976,0.0006790836,0.0005188517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004534867,"about_ca_system_score_gemma":0.0005401308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008521854,"about_ca_topic_score_gemma":0.002804931,"domain_scores_codex":[0.999892,0.00002229877,0.00001081821,0.00002209581,0.00002919435,0.00002350147],"domain_scores_gemma":[0.999859,0.00002386213,0.00003067639,0.00001297744,0.00002638575,0.00004718735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00275338,0.001603815,0.004335146,0.0004018916,0.000175473,0.000566231,0.00006537641,0.003096196,0.9441537,0.0003364451,0.001309956,0.04120249],"study_design_scores_gemma":[0.001076507,0.03426527,0.01317212,0.00005787106,0.0005631586,0.002589967,0.00009424239,0.004694459,0.9240321,0.0001747038,0.01923871,0.00004081219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983187,0.008009039,0.002333675,0.0003308739,0.00005159857,0.0002965905,0.002105613,0.0001564831,0.003529292],"genre_scores_gemma":[0.9855914,0.005090043,0.003799314,0.0001189942,0.00002473714,0.0001072968,0.003199016,0.00002705296,0.002042073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002627664,"threshold_uncertainty_score":0.008790433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153955396598612,"score_gpt":0.3513405280390305,"score_spread":0.3198009740730444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}