{"id":"W2614299484","doi":"10.1101/139733","title":"How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic diversity and population structure","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Expressivity; Allele; Genetics; Biology; Complementation; Phenotype; Drosophila melanogaster; Mutation; Gene; Epistasis; Genetic variation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001287671,0.0001557593,0.0002223371,0.0003703933,0.0002799186,0.0004842334,0.0001875322,0.0002644733,0.002154199],"category_scores_gemma":[0.004558597,0.00009089162,0.0001256303,0.0002225549,0.0005789933,0.0004189508,0.0003520632,0.0005150012,0.0002949453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002578485,"about_ca_system_score_gemma":0.0002187746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000838915,"about_ca_topic_score_gemma":0.001624235,"domain_scores_codex":[0.9991857,0.0002828493,0.00004018751,0.0001154933,0.0003040315,0.00007176925],"domain_scores_gemma":[0.9976125,0.001265526,0.0004535765,0.0001414252,0.0002324192,0.0002946492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001024234,0.0003920876,0.3282954,0.0001954673,0.0002278189,0.00370877,0.002468071,0.002339998,0.5015297,0.01019585,0.002630076,0.1469925],"study_design_scores_gemma":[0.00004024824,0.001438087,0.855157,0.00009482529,0.0001749168,0.006388797,0.004283607,0.005716306,0.1035045,0.01287994,0.01018799,0.0001338024],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919497,0.00030876,0.002750043,0.0009852664,0.00002381678,0.00001118796,0.0001006478,0.00002987743,0.003840898],"genre_scores_gemma":[0.997349,0.0001953821,0.000991391,0.000183324,0.000008692973,0.000005090645,0.00004982977,0.00001450534,0.001202751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154199,"threshold_uncertainty_score":0.0072065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885358512257242,"score_gpt":0.2524522733081465,"score_spread":0.2335986881855741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}