{"id":"W2614432952","doi":"10.1097/01.anes.0000530185.78660.da","title":"CASQ1 Gene Is an Unlikely Candidate for Malignant Hyperthermia Susceptibility in the North American Population","year":2013,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Toronto Public Health; Home and Community Care Support Services; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Calsequestrin; Malignant hyperthermia; Population; Genetics; Locus (genetics); Candidate gene; Coding region; Medicine; Allele; Gene; Biology; Anesthesia; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036986,0.0001122929,0.0001304149,0.00003694463,0.00009127356,0.00001327457,0.0001310999,0.00008582359,0.00002569355],"category_scores_gemma":[0.0000353594,0.0000776187,0.00005156877,0.0000957612,0.00008267432,0.000007241073,0.00001310667,0.00005132231,0.00001176259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001259645,"about_ca_system_score_gemma":0.00002127522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002388875,"about_ca_topic_score_gemma":0.003040202,"domain_scores_codex":[0.9990481,0.0002011622,0.0001838666,0.0003048127,0.00005507075,0.000206968],"domain_scores_gemma":[0.9994726,0.00002324501,0.00008180351,0.0003118244,0.0000711472,0.00003936175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001886612,0.0001029647,0.9384357,0.000008158643,0.00001265904,0.00000258064,0.0004131407,0.0002652494,0.04870332,0.00004295557,0.001315661,0.01050896],"study_design_scores_gemma":[0.0002506961,0.0006896715,0.9916792,8.693514e-7,0.000006006093,0.00003341779,0.0002387168,0.0008438403,0.002999513,0.0001790806,0.002958154,0.0001208708],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998912,0.00002896432,0.0001543477,0.0003714141,0.00007809145,0.0004239692,0.000008857266,0.000007014446,0.00001531424],"genre_scores_gemma":[0.9961628,0.00002430744,0.0002027069,0.002501875,0.0002303282,0.0001175159,0.0006677034,0.00001288028,0.00007986378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05324348,"threshold_uncertainty_score":0.3611281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758290286955703,"score_gpt":0.2531973912264846,"score_spread":0.2356144883569276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}