{"id":"W2614501321","doi":"10.1002/pbc.26619","title":"Impact of induction chemotherapy, hyperfractionated accelerated radiotherapy and high‐dose thiotepa on brain volume loss and functional status of children with primitive neuroectodermal tumour","year":2017,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"UCLH Biomedical Research Centre; University College London; National Institute for Health and Care Research","keywords":"ThioTEPA; Medicine; Radiation therapy; Neurotoxicity; Atrophy; Brain size; Chemotherapy; Pediatrics; Oncology; Magnetic resonance imaging; Internal medicine; Surgery; Toxicity; Radiology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003975165,0.0002134332,0.000270189,0.000281955,0.0002253207,0.0002473965,0.0002191353,0.0001808232,0.0004060363],"category_scores_gemma":[0.00166769,0.0001031561,0.0003000443,0.0002861423,0.0003464337,0.000216945,0.0002001274,0.0003893224,0.00006220774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007286546,"about_ca_system_score_gemma":0.0005296723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003378988,"about_ca_topic_score_gemma":0.004740313,"domain_scores_codex":[0.9996643,0.0001077984,0.00002582947,0.00005145614,0.00006629847,0.00008431096],"domain_scores_gemma":[0.9987016,0.0003997831,0.0005494131,0.0000362994,0.00006889754,0.0002439124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00108248,0.0001337034,0.9852805,0.00003619814,0.00008435541,0.0009072664,0.0001703717,0.0004483837,0.002397742,0.00001929294,0.0001255251,0.009314068],"study_design_scores_gemma":[0.00002759337,0.001925423,0.9943223,0.000009790508,0.00006555412,0.002370521,0.0001188626,0.0001468385,0.0006919121,0.00000783727,0.0003094796,0.000003891536],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994573,0.0003420054,0.00002309252,0.00001371952,0.000001420381,0.000003435363,0.00002785176,0.000001505673,0.0001295865],"genre_scores_gemma":[0.9996701,0.0001287488,0.00005930162,0.000009455828,0.000003943521,0.000005678984,0.00008113273,0.000001404571,0.00004031612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003378988,"threshold_uncertainty_score":0.006718636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598038360890531,"score_gpt":0.2830386003870929,"score_spread":0.2670582167781876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}