{"id":"W2614534276","doi":"10.1172/jci.insight.92056","title":"T cell progenitor therapy–facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction","year":2017,"lang":"en","type":"article","venue":"JCI Insight","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; Krembil Foundation; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Thymocyte; Progenitor cell; T cell; Haematopoiesis; Cell biology; Biology; Cell; Cell growth; Stem cell; Lymphopoiesis; In vitro; Cancer research; Immunology; Andrology; Medicine; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119679,0.0002820755,0.0002749762,0.0001761516,0.0001097635,0.0003751686,0.0001253706,0.0001770452,0.001051257],"category_scores_gemma":[0.00006235021,0.00009997216,0.0001464289,0.000089442,0.0002337591,0.0001779396,0.0002302618,0.000804217,0.00022307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188047,"about_ca_system_score_gemma":0.0002306087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001441148,"about_ca_topic_score_gemma":0.0004028541,"domain_scores_codex":[0.9998542,0.00002256714,0.00001059463,0.00002543941,0.00004416966,0.00004289964],"domain_scores_gemma":[0.999928,0.00001119818,0.00002195972,0.000007558393,0.000005943115,0.00002533461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001524067,0.00004020756,0.0003141794,0.00003124209,0.000003151051,0.00008543804,0.00001506783,0.00006513976,0.9961799,0.0001304692,0.00003575459,0.002946918],"study_design_scores_gemma":[0.00003857494,0.0009203515,0.007056891,0.00001334674,0.00003254826,0.0008872041,0.00004105145,0.0009304237,0.9873556,0.0001166865,0.002603233,0.000003910377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945284,0.001302012,0.001705102,0.00004742007,0.00001862855,0.000021174,0.0001325718,0.00005856982,0.002186215],"genre_scores_gemma":[0.9965078,0.000551994,0.001091523,0.00002845669,0.00001676155,0.00001600605,0.0001554917,0.00001296054,0.001618975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051257,"threshold_uncertainty_score":0.003516793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382511082531787,"score_gpt":0.2681374787907253,"score_spread":0.2443123679654074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}