{"id":"W2614534276","doi":"10.1172/jci.insight.92056","title":"T cell progenitor therapy–facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction","year":2017,"lang":"en","type":"article","venue":"JCI Insight","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; Krembil Foundation; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Thymocyte; Progenitor cell; T cell; Haematopoiesis; Cell biology; Biology; Cell; Cell growth; Stem cell; Lymphopoiesis; In vitro; Cancer research; Immunology; Andrology; Medicine; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001832379,0.0002774467,0.0003792946,0.0001200536,0.0002934733,0.0001143031,0.0001523625,0.0001740136,0.0002451657],"category_scores_gemma":[0.00003525123,0.0002299795,0.0001007586,0.0000463188,0.0001156981,0.0002714405,0.00004386892,0.0002455766,0.0002004485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001109158,"about_ca_system_score_gemma":0.00004777386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001033463,"about_ca_topic_score_gemma":0.00002753596,"domain_scores_codex":[0.9984819,0.00008142636,0.0003899442,0.0004497094,0.0002937912,0.0003032805],"domain_scores_gemma":[0.9988062,0.00008752751,0.0002350915,0.0006499718,0.0000539676,0.000167174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001039046,0.0004728204,0.04875759,0.0003690396,0.0001821588,0.0001438367,0.005502265,0.000001561611,0.9320445,0.00001859669,0.0007223463,0.01074621],"study_design_scores_gemma":[0.005856531,0.0005542988,0.160875,0.0002997738,0.0001906831,0.0002059089,0.0004942595,0.0001611993,0.7982796,0.00003616778,0.0326784,0.0003681013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900852,0.001159483,0.0001216135,0.0007890232,0.0004183272,0.0008772283,0.00002026111,0.0000787092,0.006450092],"genre_scores_gemma":[0.9957579,0.001485443,0.0005135661,0.0001894016,0.0001261458,0.00007122012,0.00006957396,0.00004360844,0.001743173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1337649,"threshold_uncertainty_score":0.9378294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382511082531787,"score_gpt":0.2681374787907253,"score_spread":0.2443123679654074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}