{"id":"W2614562038","doi":"10.1002/acn3.423","title":"New insights into SMA pathogenesis: immune dysfunction and neuroinflammation","year":2017,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"E-Rare; Canadian Institutes of Health Research; Cure SMA; Servier; Muscular Dystrophy Association","keywords":"Medicine; Neuroinflammation; Pathogenesis; SMA*; Immune Dysfunction; Immune system; Immunology; Neuroscience; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007084882,0.0007167366,0.0009557556,0.001250947,0.0002838804,0.001124898,0.0003832457,0.001047778,0.001766861],"category_scores_gemma":[0.000403615,0.0001470774,0.0003800727,0.0005920031,0.001146422,0.00246592,0.0008948556,0.001447276,0.0003054267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003839933,"about_ca_system_score_gemma":0.0004553967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001532514,"about_ca_topic_score_gemma":0.0003933987,"domain_scores_codex":[0.9997737,0.00007851519,0.00003165271,0.00003565577,0.00004842396,0.00003205605],"domain_scores_gemma":[0.9996616,0.0001068101,0.00008152954,0.00001868514,0.00006164482,0.00006977323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002089789,0.0007975867,0.03506512,0.009782709,0.0004073365,0.01315975,0.001634353,0.000938481,0.1953404,0.05192222,0.01953961,0.6693227],"study_design_scores_gemma":[0.0004399216,0.004517883,0.1642643,0.006152227,0.001492241,0.07360243,0.005270148,0.007789862,0.04995777,0.2102987,0.4759601,0.0002542748],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05130234,0.924284,0.004032285,0.01584918,0.001043546,0.00001977135,0.0000785181,0.00007135681,0.003319006],"genre_scores_gemma":[0.29541,0.6819437,0.00645464,0.005169834,0.007664742,0.00004532588,0.0001229535,0.00001746527,0.003171399],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001766861,"threshold_uncertainty_score":0.005910754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1117417984329839,"score_gpt":0.4106984302563246,"score_spread":0.2989566318233407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}