{"id":"W2614566686","doi":"10.3389/fncel.2017.00041","title":"JMV5656, A Novel Derivative of TLQP-21, Triggers the Activation of a Calcium-Dependent Potassium Outward Current in Microglial Cells","year":2017,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Università degli Studi di Milano-Bicocca","keywords":"Iberiotoxin; Intracellular; Chemistry; Charybdotoxin; Biophysics; Extracellular; Calcium in biology; Potassium channel; Cell biology; Channel blocker; Ion channel; Calcium; Internal medicine; Endocrinology; Biochemistry; Receptor; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103599,0.0004059536,0.0003883168,0.0001412387,0.0001832675,0.0001804738,0.0002529552,0.0003962547,0.001071478],"category_scores_gemma":[0.0001244074,0.0001128162,0.0003751416,0.0001438988,0.0002268676,0.0002962383,0.0002274425,0.000634829,0.0002888214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417119,"about_ca_system_score_gemma":0.0001506149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003935467,"about_ca_topic_score_gemma":0.0003342582,"domain_scores_codex":[0.999873,0.00001660879,0.00001777132,0.00002633931,0.0000263623,0.00003984022],"domain_scores_gemma":[0.999943,0.00000618892,0.00001882671,0.000007367953,0.000004466805,0.00002019596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002557271,0.0000229485,0.0000427234,0.00007545693,0.00000416122,0.00009104213,0.00000786995,0.00004061468,0.9986655,0.00004765349,0.00003775047,0.0007085823],"study_design_scores_gemma":[0.0001274255,0.001664812,0.002743436,0.00001454683,0.00002709181,0.0008172657,0.00003526665,0.0006818625,0.9906809,0.00007313778,0.003123789,0.00001061546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925754,0.002983663,0.001482128,0.000151028,0.00009351649,0.00007607697,0.0006127689,0.00005496414,0.001970415],"genre_scores_gemma":[0.9937901,0.001502681,0.002257711,0.00009306209,0.00003243764,0.00005563503,0.000814962,0.00001328993,0.001439981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071478,"threshold_uncertainty_score":0.003584445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03051197142730505,"score_gpt":0.272713055188911,"score_spread":0.2422010837616059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}