{"id":"W2614581899","doi":"10.1016/j.ydbio.2017.05.017","title":"CRISPR/Cas9-induced disruption of wt1a and wt1b reveals their different roles in kidney and gonad development in Nile tilapia","year":2017,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Southwest University; Natural Science Foundation of Chongqing; Specialized Research Fund for the Doctoral Program of Higher Education of China; Chongqing Science and Technology Commission; National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; Chongqing Postdoctoral Science Foundation","keywords":"Biology; Gonad; Development of the gonads; Andrology; Somatic cell; Nile tilapia; Germ cell; Yolk sac; Endocrinology; Internal medicine; Embryo; Genetics; Gene; Fish <Actinopterygii>; Fishery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150736,0.0001712086,0.0002389967,0.00007575974,0.00008982281,0.0000137973,0.000140611,0.0002368329,0.000006869046],"category_scores_gemma":[0.00005169119,0.0001286866,0.00002160003,0.00002843074,0.0001471749,0.000006552369,0.0002347362,0.0001028301,0.000001468181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004308136,"about_ca_system_score_gemma":0.00009373574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008782392,"about_ca_topic_score_gemma":0.0004960734,"domain_scores_codex":[0.9990529,0.00004861306,0.0002941191,0.0003359224,0.00004320766,0.000225224],"domain_scores_gemma":[0.9996299,0.000009430827,0.0001261324,0.0001313394,0.00001836347,0.00008488908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009390482,0.00003688156,0.2466115,0.00003233476,0.00003338689,0.000003259165,0.0003430342,2.134318e-7,0.732022,0.00006305353,0.00004001725,0.02072036],"study_design_scores_gemma":[0.0008329821,0.0000820006,0.5590116,0.0001002873,0.000002862146,0.00001832012,0.0001439623,0.000004406995,0.4375975,0.0001783837,0.001852843,0.00017484],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998513,0.0005766874,0.00001312723,0.0001637313,0.00010648,0.0001648735,0.0000151675,0.000003230669,0.0004437099],"genre_scores_gemma":[0.9983361,0.0009991516,0.0002690835,0.0001208529,0.00001947219,0.0000303028,0.0001130662,0.000009121908,0.0001028179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3124001,"threshold_uncertainty_score":0.5247687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264052735181016,"score_gpt":0.2610449941852244,"score_spread":0.2484044668334142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}