{"id":"W2614581899","doi":"10.1016/j.ydbio.2017.05.017","title":"CRISPR/Cas9-induced disruption of wt1a and wt1b reveals their different roles in kidney and gonad development in Nile tilapia","year":2017,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Southwest University; Natural Science Foundation of Chongqing; Specialized Research Fund for the Doctoral Program of Higher Education of China; Chongqing Science and Technology Commission; National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; Chongqing Postdoctoral Science Foundation","keywords":"Biology; Gonad; Development of the gonads; Andrology; Somatic cell; Nile tilapia; Germ cell; Yolk sac; Endocrinology; Internal medicine; Embryo; Genetics; Gene; Fish <Actinopterygii>; Fishery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449442,0.0002256066,0.0003037917,0.000407597,0.0002761097,0.0004805462,0.0003366232,0.0005071897,0.002563376],"category_scores_gemma":[0.0001307037,0.0003004656,0.0004683236,0.0001689072,0.000486755,0.0003620934,0.0003905735,0.0009650439,0.0007074734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004522009,"about_ca_system_score_gemma":0.0003570535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002241164,"about_ca_topic_score_gemma":0.003558077,"domain_scores_codex":[0.9997862,0.00000891357,0.0000259576,0.00007368191,0.0000544984,0.00005072292],"domain_scores_gemma":[0.9998218,0.00001725723,0.00007575916,0.00001521541,0.00001186006,0.0000579452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001247413,0.000007031138,0.0004187122,0.00003268244,0.000005845668,0.00009603458,0.00002776663,0.00008043335,0.9980972,0.0002373406,0.00005915616,0.0008130223],"study_design_scores_gemma":[0.000050042,0.0001003401,0.02276576,0.00001521533,0.00006674427,0.00096467,0.0002160659,0.002497334,0.9638292,0.0002737181,0.009191686,0.00002922272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884328,0.0006135527,0.006462381,0.0002294703,0.00008784614,0.00001866669,0.001519127,0.0002760451,0.002360041],"genre_scores_gemma":[0.9873532,0.0003274843,0.00266161,0.00014629,0.000007497869,0.00003230795,0.0009849318,0.0001279134,0.008358864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002563376,"threshold_uncertainty_score":0.00857538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264052735181016,"score_gpt":0.2610449941852244,"score_spread":0.2484044668334142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}