{"id":"W2614858049","doi":"","title":"Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A","year":2016,"lang":"en","type":"article","venue":"PMC","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Regina","funders":"","keywords":"Homologous desensitization; Desensitization (medicine); Prostaglandin E2; Eicosanoid; Protein kinase A; Prostaglandin E2 receptor; Receptor; Sensitization; Endocrinology; Chemistry; Nociceptor; Internal medicine; Kinase; Pharmacology; Cell biology; Nociception; Biology; Neuroscience; Medicine; Agonist; Biochemistry; Arachidonic acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006298486,0.00008109109,0.0001176198,0.00004184576,0.00001443457,0.000002281167,0.00006809238,0.00009987502,0.0000280714],"category_scores_gemma":[0.0002373454,0.00006000447,0.00003646797,0.00008166303,0.00004245142,0.000004301228,0.00004064756,0.00001909422,0.000006591074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007150327,"about_ca_system_score_gemma":0.0000391974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001481371,"about_ca_topic_score_gemma":0.000008364644,"domain_scores_codex":[0.9994459,0.00003915219,0.0001621286,0.0001567123,0.00008436712,0.0001117454],"domain_scores_gemma":[0.9994844,0.000009692762,0.000104348,0.0002006534,0.0001549211,0.00004603367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008852458,0.00004243411,0.007170243,0.00002376024,0.00001809106,8.478361e-7,0.00005189736,0.000004004045,0.9841568,0.00003253345,0.0001670256,0.00824385],"study_design_scores_gemma":[0.0003503134,0.0002397922,0.04286221,0.0000574001,0.00000660584,0.000001931467,0.00001369609,2.619711e-7,0.9554233,0.000007283152,0.0009607738,0.00007641903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953824,0.000207163,0.003922947,0.0001019235,0.00005688011,0.0002331634,0.00003113774,0.000007475559,0.00005696144],"genre_scores_gemma":[0.9985813,0.00008619448,0.0006078191,0.00003217814,0.00009120085,0.00002104008,0.00006561181,0.00001267504,0.0005019932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03569197,"threshold_uncertainty_score":0.2446911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008980647386956966,"score_gpt":0.2330781816900273,"score_spread":0.2240975343030703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}