{"id":"W2614863031","doi":"10.1021/acs.jnatprod.7b00152","title":"Furan and Lactam Jadomycin Biosynthetic Congeners Isolated from <i>Streptomyces venezuelae</i> ISP5230 Cultured with <i>N</i><sub>ε</sub>-Trifluoroacetyl-<scp>l</scp>-lysine","year":2017,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts","keywords":"Stereochemistry; Chemistry; Streptomyces; Biosynthesis; Amide; Actinomycetales; Lysine; Tandem mass spectrometry; Streptomycetaceae; Lactam; Aldehyde; Mass spectrometry; Bacteria; Biochemistry; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005708839,0.0005969149,0.001184009,0.000233551,0.0005002448,0.0003491345,0.0005292273,0.0003087073,0.00001121327],"category_scores_gemma":[0.002453743,0.0003584727,0.0002299231,0.0003388511,0.0005226666,0.0008453238,0.0001378832,0.001231782,0.00001692377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001061006,"about_ca_system_score_gemma":0.000255231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005712095,"about_ca_topic_score_gemma":0.00002992256,"domain_scores_codex":[0.9969795,0.0001285687,0.0008246111,0.000768142,0.0007000224,0.0005991975],"domain_scores_gemma":[0.9956967,0.0001823236,0.001568051,0.0009096648,0.001273592,0.0003696793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001049918,0.0001843256,0.001088267,0.0001453538,0.0007000237,0.0003188532,0.0002810521,0.000001708087,0.9670787,0.000004699102,0.01473424,0.01441287],"study_design_scores_gemma":[0.003479805,0.0007564703,0.008756632,0.000771556,0.0009906034,0.001809967,0.0002425286,0.00003123231,0.9688519,0.00002959032,0.01400442,0.0002753187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663,0.01688799,0.000002934122,0.01487229,0.001109334,0.0005655165,0.00004707618,0.00005226856,0.0001625625],"genre_scores_gemma":[0.9925808,0.002509589,0.001820433,0.0005820635,0.001892382,8.203255e-7,0.00003440992,0.000067883,0.000511562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02628083,"threshold_uncertainty_score":0.9998868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008936257910112278,"score_gpt":0.22146790969846,"score_spread":0.2125316517883478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}