{"id":"W2614863031","doi":"10.1021/acs.jnatprod.7b00152","title":"Furan and Lactam Jadomycin Biosynthetic Congeners Isolated from <i>Streptomyces venezuelae</i> ISP5230 Cultured with <i>N</i><sub>ε</sub>-Trifluoroacetyl-<scp>l</scp>-lysine","year":2017,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts","keywords":"Stereochemistry; Chemistry; Streptomyces; Biosynthesis; Amide; Actinomycetales; Lysine; Tandem mass spectrometry; Streptomycetaceae; Lactam; Aldehyde; Mass spectrometry; Bacteria; Biochemistry; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000520801,0.0002788523,0.0001635261,0.0001969009,0.0001326263,0.0001956695,0.0001019295,0.0001061119,0.000450178],"category_scores_gemma":[0.0001185149,0.00007306954,0.0001100257,0.0003021709,0.0001119373,0.0001168707,0.0001071201,0.0002611316,0.0001207788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001858889,"about_ca_system_score_gemma":0.0002429244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002722773,"about_ca_topic_score_gemma":0.00477599,"domain_scores_codex":[0.9999443,0.000008696,0.00000600339,0.00001539933,0.00001091832,0.00001461456],"domain_scores_gemma":[0.9999394,0.000009275904,0.0000190441,0.000009235458,0.0000105426,0.00001251092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009614765,0.00001327399,0.0004764806,0.00002043403,0.000002535476,0.00005367328,0.00001510074,0.00004670386,0.9973321,0.00001724148,0.00001096284,0.00191534],"study_design_scores_gemma":[0.00001485012,0.0007571063,0.02157258,0.00001381563,0.00003667321,0.0003818173,0.0001070794,0.0002151334,0.9733605,0.00003216052,0.003500206,0.000008021443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968836,0.000531466,0.0004906064,0.00002052967,0.000007755953,0.00002759534,0.0005078748,0.00001628982,0.00151439],"genre_scores_gemma":[0.995363,0.0004157475,0.001754456,0.00001894106,0.000005124399,0.00001425228,0.001479009,0.00001124317,0.0009382167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002722773,"threshold_uncertainty_score":0.00541389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008936257910112278,"score_gpt":0.22146790969846,"score_spread":0.2125316517883478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}