{"id":"W2614881333","doi":"10.3389/fnins.2017.00281","title":"Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease","year":2017,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; Servier; Greta och Johan Kocks stiftelser; Vetenskapsrådet; Eisai; Lunds Universitet; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Gyllenstiernska Krapperupsstiftelsen; F. Hoffmann-La Roche; Stiftelsen Bundy Academy; Synarc; University of Southern California; Medpace; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Cognition; Disease; Cognitive decline; Medicine; Neuroimaging; Alzheimer's disease; Pathology; Psychology; Dementia; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002603261,0.0003642375,0.0002836055,0.001214318,0.0002422589,0.0005816136,0.0003784942,0.0005084307,0.001170954],"category_scores_gemma":[0.006175793,0.000264052,0.0006467566,0.0008541897,0.0004022929,0.0006828767,0.000623135,0.0005652197,0.0001861876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001831464,"about_ca_system_score_gemma":0.0003783327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002187214,"about_ca_topic_score_gemma":0.00231544,"domain_scores_codex":[0.9997005,0.00009068168,0.00003933587,0.00009461561,0.00004192753,0.0000328587],"domain_scores_gemma":[0.9937045,0.001978013,0.002878028,0.0004057282,0.0004118326,0.0006217936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000226252,0.00002821791,0.9977213,0.000009043695,0.00004144205,0.00003379222,0.00005779705,0.00020117,0.000351192,0.00002223038,0.00001729503,0.001290354],"study_design_scores_gemma":[0.000003391739,0.0001078102,0.998519,0.000004850076,0.00002794187,0.0001728364,0.00004233724,0.0008855566,0.0001193262,0.00007330751,0.00004030408,0.000003180269],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988593,0.0002572736,0.0005926095,0.0000188747,0.000002558064,0.000004418936,0.0001005556,0.000005646237,0.0001588134],"genre_scores_gemma":[0.9990411,0.00009404276,0.0005708227,0.000006628643,0.000006353001,0.000004993989,0.000192849,0.00000173798,0.00008147187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002603261,"threshold_uncertainty_score":0.01376754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06184257665175103,"score_gpt":0.3852332790679701,"score_spread":0.3233907024162191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}