{"id":"W2614917637","doi":"10.1053/j.gastro.2017.05.012","title":"Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers","year":2017,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Chonnam National University Hwasun Hospital; Chungnam National University Hospital; Pusan National University; Dong-A University; Chungnam National University; National Cancer Institute; Chonnam National University; Kosin University; DeGregorio Family Foundation","keywords":"KRAS; RHOA; CDH1; Somatic cell; Cancer; Germline mutation; Exome sequencing; Exome; Germline; CDKN2A; Cancer research; Age of onset; Frameshift mutation; Biology; Medicine; Oncology; Internal medicine; Gene; Mutation; Genetics; Colorectal cancer; Cell; Cadherin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424484,0.0002582661,0.0003357823,0.001165388,0.0002412746,0.0003531493,0.0001456678,0.0002581767,0.002681654],"category_scores_gemma":[0.0004965244,0.0001418815,0.0001784193,0.0007217588,0.0002489145,0.0001277976,0.0002577377,0.0001634619,0.0004217873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570288,"about_ca_system_score_gemma":0.0001413495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008928082,"about_ca_topic_score_gemma":0.00169092,"domain_scores_codex":[0.9998208,0.00001642383,0.00001852543,0.00005714283,0.00004828881,0.00003893496],"domain_scores_gemma":[0.9995692,0.00007169157,0.0001552009,0.00004655375,0.00005249236,0.0001048167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001135208,0.00006093669,0.7603654,0.0001633097,0.0001280743,0.002466826,0.0002790248,0.00006902879,0.2087164,0.0002071165,0.0004371462,0.02597149],"study_design_scores_gemma":[0.0000164685,0.0001004137,0.9750108,0.000007672255,0.00005832658,0.01157323,0.0002092603,0.0001113102,0.01066951,0.0001177166,0.002118489,0.000006790847],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969723,0.001020745,0.0003576172,0.00001945948,0.000006095504,0.000007134261,0.0003872463,0.0000348494,0.001194599],"genre_scores_gemma":[0.9985083,0.0002572796,0.000184135,0.000008117948,0.000006138646,0.000004184464,0.0003901747,0.00000941544,0.0006322111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002681654,"threshold_uncertainty_score":0.008970976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002663571439846,"score_gpt":0.2344029235415446,"score_spread":0.2243762878271461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}