{"id":"W2614917637","doi":"10.1053/j.gastro.2017.05.012","title":"Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers","year":2017,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Chonnam National University Hwasun Hospital; Chungnam National University Hospital; Pusan National University; Dong-A University; Chungnam National University; National Cancer Institute; Chonnam National University; Kosin University; DeGregorio Family Foundation","keywords":"KRAS; RHOA; CDH1; Somatic cell; Cancer; Germline mutation; Exome sequencing; Exome; Germline; CDKN2A; Cancer research; Age of onset; Frameshift mutation; Biology; Medicine; Oncology; Internal medicine; Gene; Mutation; Genetics; Colorectal cancer; Cell; Cadherin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001619804,0.0003380382,0.0005629129,0.0001640786,0.000255547,0.00004074407,0.0006190471,0.0001521658,0.0001134207],"category_scores_gemma":[0.00006519222,0.0003162226,0.0001211732,0.00007804503,0.0006982808,0.00003009782,0.00009517229,0.0001655695,0.000006254636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001439574,"about_ca_system_score_gemma":0.000530917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003002478,"about_ca_topic_score_gemma":0.003605971,"domain_scores_codex":[0.9978957,0.0001346045,0.000703809,0.0004763562,0.0002530047,0.0005365432],"domain_scores_gemma":[0.9978564,0.00002598522,0.000908617,0.0008236758,0.0002425305,0.0001427727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002745086,0.0001158624,0.9375122,0.0001327119,0.0004084995,0.00001753492,0.0003619637,0.001109045,0.05962616,0.000008967204,0.0003744309,0.00005817026],"study_design_scores_gemma":[0.005512947,0.001434948,0.940302,0.0003475696,0.0002857453,0.000118235,0.000298841,0.000429498,0.05026972,0.0005774074,0.00001015032,0.0004129288],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964928,0.0001570044,0.00197054,0.000205591,0.0002839475,0.0004065658,0.0003965755,0.00001791537,0.00006904913],"genre_scores_gemma":[0.9940446,0.00008912275,0.004755193,0.0001289681,0.00007771599,0.000154972,0.0005629126,0.0000411003,0.0001453904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009356447,"threshold_uncertainty_score":0.999929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002663571439846,"score_gpt":0.2344029235415446,"score_spread":0.2243762878271461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}