{"id":"W2615129326","doi":"10.1038/nm.4335","title":"Metformin ameliorates core deficits in a mouse model of fragile X syndrome","year":2017,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":238,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Wellcome Trust; Fondation Brain Canada; FRAXA Research Foundation","keywords":"Fragile X syndrome; Metformin; FMR1; PI3K/AKT/mTOR pathway; Translation (biology); MAPK/ERK pathway; Phosphorylation; Fragile x; Autism spectrum disorder; Autism; Medicine; Endocrinology; Phenotype; Internal medicine; Neuroscience; Diabetes mellitus; Signal transduction; Biology; Messenger RNA; Genetics; Psychiatry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545337,0.001118845,0.0004673759,0.001133761,0.0003043245,0.0003375444,0.0005198541,0.0008266479,0.002261402],"category_scores_gemma":[0.0002447062,0.000338799,0.0004210676,0.0002397801,0.0005069359,0.0004165892,0.0004225739,0.001229454,0.0004208652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004544462,"about_ca_system_score_gemma":0.0004662057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270639,"about_ca_topic_score_gemma":0.002437277,"domain_scores_codex":[0.9998425,0.00002358445,0.00002068386,0.00003373971,0.00004272871,0.0000367639],"domain_scores_gemma":[0.9996328,0.000030205,0.0001550306,0.00003179886,0.00002233328,0.0001278262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001377996,0.0002308212,0.0003770833,0.00005775915,0.00003435713,0.0003014372,0.00002472498,0.0003451047,0.9929278,0.000525386,0.0002918672,0.003505693],"study_design_scores_gemma":[0.000644394,0.003753605,0.01361711,0.00007253312,0.0002290809,0.001289128,0.0001428768,0.003560678,0.9699473,0.001204085,0.005487981,0.00005125271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99411,0.0008476148,0.002010552,0.000403301,0.0001282301,0.00003617505,0.0008140936,0.0003663905,0.001283544],"genre_scores_gemma":[0.9902913,0.001370186,0.002322079,0.0001493845,0.0000346486,0.00007664223,0.0005686582,0.0001070337,0.00508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002261402,"threshold_uncertainty_score":0.007565141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773364482364145,"score_gpt":0.2790214136627245,"score_spread":0.2612877688390831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}