{"id":"W2615223867","doi":"10.1016/j.pharmthera.2017.05.006","title":"Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity","year":2017,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"European Food Safety Authority","keywords":"Adverse Outcome Pathway; Mechanism (biology); Disease; Neurotoxicity; Neuroscience; Adverse effect; Bioinformatics; Biology; Computational biology; Medicine; Toxicity; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002364683,0.0004986771,0.001792944,0.0002444182,0.0001842901,0.00001040426,0.0003742609,0.0002932628,0.00009936618],"category_scores_gemma":[0.00001112777,0.0004217607,0.0004880319,0.0001693039,0.00008993666,0.00004191366,0.0001230761,0.0003718613,0.0001574378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005232869,"about_ca_system_score_gemma":0.0003302683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005660426,"about_ca_topic_score_gemma":0.000001997803,"domain_scores_codex":[0.9978926,0.0001631011,0.0006758173,0.0006047743,0.000268633,0.0003950347],"domain_scores_gemma":[0.9980821,0.000140387,0.0007735855,0.0006543439,0.00008215214,0.0002674082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003895035,0.001657742,0.00008100911,0.01587073,0.005175397,0.0003207043,0.0001444808,0.00000376342,0.004683862,0.001626017,0.0001349888,0.9699118],"study_design_scores_gemma":[0.0007505689,0.0003698334,0.00001623087,0.001121055,0.01564704,0.00003882435,0.00001413272,0.00008630071,0.001089811,0.0004264152,0.9801135,0.0003262718],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002083611,0.9737153,0.01870919,0.0001501313,0.001038235,0.005110949,0.000324312,0.0001186352,0.0006248771],"genre_scores_gemma":[0.02455659,0.9724904,0.0003889338,0.001293795,0.0001740602,0.0006974845,0.00008436975,0.00009739467,0.0002169883],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9799785,"threshold_uncertainty_score":0.9998235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2925643406777864,"score_gpt":0.4757640480739471,"score_spread":0.1831997073961608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}