{"id":"W2615366920","doi":"10.1101/139758","title":"Dynamics of the Human Antibody Repertoire following B-cell Depletion in Systemic Sclerosis","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Immunoglobulin D; Antibody; B cell; Biology; Autoantibody; Immunoglobulin light chain; B-cell receptor; Immunology; Germline mutation; Immune system; Somatic hypermutation; Mutation; Antibody Repertoire; Immunoglobulin heavy chain; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292021,0.00006245686,0.0001060974,0.0002077054,0.00005872624,0.0001415755,0.0000710696,0.00009485454,0.001148653],"category_scores_gemma":[0.0001441714,0.00004312404,0.00005621031,0.0001229609,0.00006924745,0.00006954213,0.00009582834,0.0001234052,0.0002726158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006936364,"about_ca_system_score_gemma":0.00004558367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003195431,"about_ca_topic_score_gemma":0.0002576271,"domain_scores_codex":[0.999947,0.00001191879,0.00000373153,0.00001016936,0.0000156414,0.0000116146],"domain_scores_gemma":[0.9999104,0.00003574458,0.0000178434,0.000008646988,0.0000147366,0.00001253419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002974511,0.00002388354,0.008269235,0.00003097789,0.00001140015,0.0001078333,0.0000436625,0.0002089798,0.9819568,0.00005243834,0.00006008113,0.008937254],"study_design_scores_gemma":[0.00003155788,0.001133897,0.3585676,0.00002081403,0.00006016024,0.001925101,0.0001246871,0.005627352,0.6273145,0.0002906296,0.004893697,0.00001000632],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976022,0.0006869037,0.0008230272,0.00000921679,0.000002262776,0.000005091708,0.0001401584,0.00002093987,0.0007103434],"genre_scores_gemma":[0.9987141,0.0001995403,0.0003556246,0.00001613131,0.000002424999,0.000007040765,0.0002294934,0.000004714961,0.00047094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148653,"threshold_uncertainty_score":0.003842592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01934707592014306,"score_gpt":0.2471515991711929,"score_spread":0.2278045232510498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}