{"id":"W2615464599","doi":"10.1007/s12035-017-0570-y","title":"Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32","year":2017,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institutes of Health; Horizon 2020; Fonds National de la Recherche Luxembourg; Deutsches Krebsforschungszentrum","keywords":"LRRK2; microRNA; Mutant; Biology; Disease; Gene; Function (biology); Mutation; Parkinson's disease; Kinase; Genetics; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046727,0.0002904393,0.0003084436,0.0001189222,0.0001403371,0.0001991199,0.0002269936,0.0002603338,0.001520181],"category_scores_gemma":[0.0001779154,0.0001046508,0.0002521047,0.00005748169,0.0002377214,0.0001744593,0.0002721066,0.0003887769,0.0006407238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737925,"about_ca_system_score_gemma":0.0001735524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819839,"about_ca_topic_score_gemma":0.0003164273,"domain_scores_codex":[0.9998665,0.00003483184,0.00001105689,0.00003043661,0.00002671035,0.00003047998],"domain_scores_gemma":[0.9999208,0.00001255979,0.00002720835,0.00001220633,0.000006847863,0.00002046919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000914878,0.00001432085,0.0001053132,0.00002720441,0.000004865267,0.0001346285,0.000008381988,0.00004410989,0.9985126,0.00015835,0.00004721395,0.0008514478],"study_design_scores_gemma":[0.00003986982,0.0004635353,0.004359732,0.000009512401,0.00001707902,0.001501554,0.00003068957,0.001451439,0.9888132,0.0002329152,0.003073782,0.000006683772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892953,0.003056891,0.00315379,0.0001925824,0.00003886399,0.00002537163,0.0001343734,0.0001153416,0.003987367],"genre_scores_gemma":[0.9970571,0.0004781361,0.001016271,0.00006324812,0.000005880383,0.00002053485,0.0001324376,0.00001653353,0.001209878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520181,"threshold_uncertainty_score":0.005085528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008892501575069038,"score_gpt":0.2450959420765658,"score_spread":0.2362034405014967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}