{"id":"W2615601352","doi":"10.3390/cancers9050052","title":"Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways","year":2017,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":1973,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"Cyclin-dependent kinase 8; Cancer research; Epidermal growth factor receptor; Signal transduction; Protein kinase B; MAPK/ERK pathway; ERBB3; Receptor tyrosine kinase; Biology; PI3K/AKT/mTOR pathway; Growth factor receptor; Cell cycle; Cell biology; Cancer; Notch signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891503,0.0007098016,0.0007018961,0.001272954,0.0002551348,0.0008061189,0.0005768893,0.0005243036,0.00636301],"category_scores_gemma":[0.0001847756,0.0001714559,0.0004159119,0.000999207,0.0002203564,0.0006469098,0.000504795,0.001388021,0.003941966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005626137,"about_ca_system_score_gemma":0.0007090042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008920821,"about_ca_topic_score_gemma":0.001301521,"domain_scores_codex":[0.999869,0.00001424299,0.00001597418,0.00002195417,0.00006128938,0.0000175304],"domain_scores_gemma":[0.9999417,0.00001389384,0.000009137524,0.000002433549,0.00002498276,0.00000777047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008358866,0.00009493948,0.000189983,0.01278572,0.00008684397,0.0002792972,0.00006544426,0.0004322734,0.009541883,0.007047167,0.04159795,0.9277951],"study_design_scores_gemma":[0.00001115079,0.00005086442,0.0004026223,0.0008205752,0.00003759187,0.0007198076,0.00002165128,0.00006092285,0.001900332,0.00101794,0.9949469,0.00000959828],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005397857,0.9896178,0.0003920809,0.0003959297,0.0003781549,0.00002049265,0.0001335165,0.00003133793,0.008490896],"genre_scores_gemma":[0.002355834,0.992543,0.0002789204,0.0002204292,0.0001424572,0.00001571512,0.0001570587,0.000002609379,0.004283939],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00636301,"threshold_uncertainty_score":0.02128637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1574054824547146,"score_gpt":0.3949922547634476,"score_spread":0.2375867723087331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}