{"id":"W2615682460","doi":"10.1002/ijc.30709","title":"Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer","year":2017,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"FP7 Health; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; European Research Council; Medical Research Council; National Institutes of Health; Kuopion Yliopistollinen Sairaala; NordForsk; China Scholarship Council; Jane ja Aatos Erkon Säätiö; Opetus- ja Kulttuuriministeriö; Pfizer; National Institute for Social Care and Health Research; Tenovus; National Institute for Health and Care Research; Academy of Finland; Cancer Research UK; Netherlands eScience Center; Wellcome Trust; Cancer Research Wales; Wellcome; California Department of Public Health; European Commission","keywords":"Internal medicine; Medicine; Odds ratio; Colorectal cancer; Single-nucleotide polymorphism; Mendelian randomization; Confidence interval; Risk factor; Oncology; Endocrinology; Gastroenterology; Cancer; Genetics; Genotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07740603,0.001346323,0.003111966,0.001243865,0.0007113842,0.001438657,0.001396722,0.001975522,0.003235297],"category_scores_gemma":[0.1225956,0.0008040793,0.002213831,0.001683765,0.002374641,0.001323745,0.001005575,0.001898202,0.0005060075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001105473,"about_ca_system_score_gemma":0.001801801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003226733,"about_ca_topic_score_gemma":0.002284406,"domain_scores_codex":[0.9072073,0.07446822,0.003368728,0.007578366,0.006064659,0.001312824],"domain_scores_gemma":[0.9443643,0.03615718,0.005468269,0.01216294,0.001490711,0.0003564452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.04562899,0.001276851,0.3741627,0.005794913,0.05407596,0.00617697,0.003673073,0.02991226,0.01657622,0.2177436,0.01775202,0.2272264],"study_design_scores_gemma":[0.02292059,0.01611342,0.2522574,0.001437918,0.02485435,0.01124026,0.000810534,0.2227911,0.01168081,0.3849663,0.05028474,0.0006427062],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2698369,0.00872873,0.6939039,0.00420922,0.001993018,0.009147226,0.001668116,0.001692516,0.008820373],"genre_scores_gemma":[0.9000505,0.001592264,0.08561864,0.001839242,0.0002915801,0.006160616,0.0006506743,0.0001317964,0.003664792],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.07740603,"threshold_uncertainty_score":0.4093671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351722520297714,"score_gpt":0.3414147088500616,"score_spread":0.3278974836470844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}