{"id":"W2615682460","doi":"10.1002/ijc.30709","title":"Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer","year":2017,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"FP7 Health; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; European Research Council; Medical Research Council; National Institutes of Health; Kuopion Yliopistollinen Sairaala; NordForsk; China Scholarship Council; Jane ja Aatos Erkon Säätiö; Opetus- ja Kulttuuriministeriö; Pfizer; National Institute for Social Care and Health Research; Tenovus; National Institute for Health and Care Research; Academy of Finland; Cancer Research UK; Netherlands eScience Center; Wellcome Trust; Cancer Research Wales; Wellcome; California Department of Public Health; European Commission","keywords":"Internal medicine; Medicine; Odds ratio; Colorectal cancer; Single-nucleotide polymorphism; Mendelian randomization; Confidence interval; Risk factor; Oncology; Endocrinology; Gastroenterology; Cancer; Genetics; Genotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759242,0.0001192748,0.0001912022,0.00005680819,0.0001326135,0.0001057855,0.0004845516,0.00008992599,0.0001511985],"category_scores_gemma":[0.0002889879,0.0001000747,0.0002292605,0.00001198863,0.00006361802,0.00002497302,0.00005310751,0.00009834909,0.000001799768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008252488,"about_ca_system_score_gemma":0.0003543792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004877505,"about_ca_topic_score_gemma":0.0006705986,"domain_scores_codex":[0.9991291,0.00002200063,0.0003001495,0.0001610723,0.000243238,0.0001444217],"domain_scores_gemma":[0.9982829,0.00002430634,0.0007353728,0.0001350123,0.0007370925,0.00008532248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00514285,0.00004905241,0.02640479,0.00001013277,0.001155056,2.626358e-7,0.0002261914,0.0003966937,0.6695545,0.0001318705,0.01696819,0.2799604],"study_design_scores_gemma":[0.007687408,0.0001614119,0.06994215,0.00005672403,0.0001359661,0.00002826626,0.00004448123,0.0000737621,0.1961648,0.0003261988,0.7251856,0.0001932825],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694866,0.006210607,0.0009251009,0.001487831,0.02081689,0.000196379,0.0006232866,0.000003641726,0.0002496782],"genre_scores_gemma":[0.9570214,0.01053981,0.0002151186,0.0002482721,0.03154493,0.00007230644,0.00001036967,0.00001973137,0.0003280963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7082174,"threshold_uncertainty_score":0.4080927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351722520297714,"score_gpt":0.3414147088500616,"score_spread":0.3278974836470844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}