{"id":"W2615766380","doi":"10.1182/blood.v128.22.1148.1148","title":"First in Human Study with GSK2857916, an Antibody Drug Conjugated to Microtubule-Disrupting Agent Directed Against B-Cell Maturation Antigen (BCMA) in Patients with Relapsed/Refractory Multiple Myeloma (MM): Results from Study BMA117159 Part 1 Dose Escalation","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Multiple myeloma; Antibody; Pharmacology; Immunology; Pharmacokinetics; Plasma cell; Transplantation; Cancer research; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001227986,0.001242167,0.002627612,0.0004355687,0.0005025024,0.0009143336,0.000491377,0.001126446,0.004195981],"category_scores_gemma":[0.0008100893,0.0003535356,0.00212673,0.0004016267,0.0007957182,0.0007586317,0.0003585803,0.002361662,0.001160342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001042768,"about_ca_system_score_gemma":0.0008144481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009797567,"about_ca_topic_score_gemma":0.001754981,"domain_scores_codex":[0.9993327,0.0002474108,0.0000468175,0.0001768307,0.00007926161,0.0001169549],"domain_scores_gemma":[0.9992594,0.0001253324,0.0001372644,0.0001163079,0.00006510879,0.0002965285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.528695,0.06555873,0.03284754,0.001739525,0.004553061,0.001387513,0.0007649016,0.002550874,0.1483705,0.0004399848,0.007053395,0.2060389],"study_design_scores_gemma":[0.08835052,0.8365043,0.0443794,0.00005647141,0.001829287,0.0007536756,0.00009688029,0.0006578968,0.01763223,0.0002350065,0.009452678,0.00005156424],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844441,0.005914491,0.0009288402,0.0003819642,0.0001280571,0.001798747,0.002719112,0.0001343982,0.003550248],"genre_scores_gemma":[0.9869907,0.002397128,0.0009963068,0.0007825498,0.0001726071,0.0009521714,0.003499833,0.00004877884,0.004159898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004195981,"threshold_uncertainty_score":0.01403695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609402546199887,"score_gpt":0.2762876653695559,"score_spread":0.260193639907557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}