{"id":"W2615906896","doi":"10.3390/antib6020007","title":"Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function","year":2017,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Zymeworks (Canada)","funders":"Centers for Disease Control and Prevention","keywords":"Effector; Fragment crystallizable region; Antibody-dependent cell-mediated cytotoxicity; Protein engineering; Antibody; Epitope; Context (archaeology); Function (biology); Biology; Biophysics; Chemistry; Cell biology; Monoclonal antibody; Biochemistry; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002218225,0.0004635248,0.0002042962,0.0003549742,0.0001233152,0.0003541282,0.0004171877,0.0004192093,0.0008338061],"category_scores_gemma":[0.0002258826,0.0001473518,0.0001954537,0.0002670769,0.0001750595,0.0003101264,0.0003186985,0.0006099877,0.0004353427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005185782,"about_ca_system_score_gemma":0.0001605007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003926556,"about_ca_topic_score_gemma":0.0005812277,"domain_scores_codex":[0.9997408,0.00003771246,0.00002270994,0.00004577862,0.0001019889,0.00005094176],"domain_scores_gemma":[0.9999014,0.00001387611,0.00003837686,0.00001014382,0.00002125423,0.00001492414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000434965,0.00003348109,0.00006444109,0.00003269437,0.000005574144,0.0000404301,0.00001453009,0.0005059853,0.9940898,0.0009514553,0.00007806308,0.004140091],"study_design_scores_gemma":[0.000009551885,0.00007597905,0.000163797,0.000002845297,0.000009005889,0.0001099592,0.000005243434,0.002533664,0.9940338,0.0001057056,0.002946557,0.000003906368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9157618,0.001400244,0.07486732,0.0001657574,0.00007932531,0.0001022852,0.0002031566,0.0002648056,0.007155245],"genre_scores_gemma":[0.9707978,0.0007089106,0.02453811,0.0001516313,0.00001550945,0.0000730795,0.0002518365,0.00005590965,0.003407297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008338061,"threshold_uncertainty_score":0.003762543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03435150278124715,"score_gpt":0.3166015176457345,"score_spread":0.2822500148644874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}