{"id":"W2615906896","doi":"10.3390/antib6020007","title":"Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function","year":2017,"lang":"en","type":"article","venue":"Antibodies","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Zymeworks (Canada)","funders":"Centers for Disease Control and Prevention","keywords":"Effector; Fragment crystallizable region; Antibody-dependent cell-mediated cytotoxicity; Protein engineering; Antibody; Epitope; Context (archaeology); Function (biology); Biology; Biophysics; Chemistry; Cell biology; Monoclonal antibody; Biochemistry; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002714122,0.0003180298,0.0005325312,0.0003590949,0.0008079759,0.0001971464,0.0002409852,0.0001107219,0.00004890474],"category_scores_gemma":[0.000420541,0.0002218443,0.0002111669,0.0001517439,0.0002440323,0.000258795,0.0001111838,0.00024912,0.0001431437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004138886,"about_ca_system_score_gemma":0.00007351138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001232946,"about_ca_topic_score_gemma":0.00002738198,"domain_scores_codex":[0.9982399,0.000018138,0.0002565349,0.0004561773,0.0004354194,0.0005937723],"domain_scores_gemma":[0.9984866,0.0002612727,0.0001426875,0.0006237064,0.0002985115,0.0001872013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0136965,0.0006636744,0.5732619,0.004415945,0.002461946,0.0003788173,0.0004153095,0.00004301139,0.2750441,0.007444818,0.04178521,0.08038871],"study_design_scores_gemma":[0.002356135,0.002479434,0.8572835,0.0005240768,0.0002466058,0.0001145795,0.00006859755,0.000885395,0.04361516,0.00008045352,0.0918749,0.0004711375],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856593,0.002051608,0.0008375174,0.001867239,0.0006269761,0.0009176288,0.00008061575,0.0001564232,0.007802661],"genre_scores_gemma":[0.9872437,0.0008662136,0.003072937,0.00009364481,0.0008468766,0.00006547292,0.0001198692,0.00006020401,0.007631051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2840216,"threshold_uncertainty_score":0.9046549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03435150278124715,"score_gpt":0.3166015176457345,"score_spread":0.2822500148644874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}