{"id":"W2615972939","doi":"10.1074/jbc.m117.789263","title":"Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"HRAS; Phosphatidylinositol; Phosphoinositide 3-kinase; Chemistry; PI3K/AKT/mTOR pathway; Cell biology; Signal transduction; GTPase; Kinase; Biochemistry; Biology; KRAS","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007337075,0.0003101903,0.00008978519,0.0001328548,0.0001382666,0.0002295573,0.0001976247,0.000194495,0.0006778703],"category_scores_gemma":[0.00003122322,0.00009496116,0.0001083589,0.00009985525,0.0001940064,0.0002164666,0.0001242398,0.0003286811,0.0002225396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003676602,"about_ca_system_score_gemma":0.000277917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004305374,"about_ca_topic_score_gemma":0.0003517071,"domain_scores_codex":[0.9999634,0.000003937841,0.000002049564,0.00001037889,0.0000129461,0.00000730291],"domain_scores_gemma":[0.9999913,9.368719e-7,0.000002958923,8.985353e-7,0.000001099328,0.00000279821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00012094,0.00002830899,0.0003005803,0.00009577574,0.000008231458,0.0001063898,0.000008617975,0.0002437477,0.9939387,0.001466926,0.0001569854,0.003524932],"study_design_scores_gemma":[0.00002051081,0.0001152512,0.00292771,0.000004779603,0.00001730656,0.0004519967,0.00001604731,0.001671627,0.9887769,0.0004100101,0.005581804,0.000006110187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681381,0.01103339,0.01218188,0.0005199799,0.00009212355,0.00009094398,0.0009033612,0.0002070937,0.006833192],"genre_scores_gemma":[0.990373,0.004522528,0.002401788,0.00005724693,0.00001011329,0.00003271689,0.0003303605,0.000006483955,0.002265762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006778703,"threshold_uncertainty_score":0.002667546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617010352345299,"score_gpt":0.2803375968347782,"score_spread":0.2641674933113252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}