{"id":"W2615999950","doi":"10.1007/s40262-017-0548-y","title":"Penetration of Vancomycin into the Cerebrospinal Fluid: A Systematic Review","year":2017,"lang":"en","type":"review","venue":"Clinical Pharmacokinetics","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of Alberta; Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Vancomycin; Ventriculitis; Medicine; Cerebrospinal fluid; Penetration (warfare); Meningitis; Internal medicine; Surgery; Staphylococcus aureus; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001956332,0.001385284,0.005562672,0.004391184,0.0002930681,0.002183197,0.001616938,0.001674678,0.003530798],"category_scores_gemma":[0.006996304,0.0006100185,0.004954895,0.005386943,0.0005793808,0.001867321,0.001165245,0.001078307,0.0003516675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001159409,"about_ca_system_score_gemma":0.004612082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004591424,"about_ca_topic_score_gemma":0.01222247,"domain_scores_codex":[0.9987317,0.0002325648,0.0005317424,0.0001849206,0.0002512585,0.00006789577],"domain_scores_gemma":[0.9958999,0.002687342,0.0009507405,0.00005673697,0.0003241173,0.00008127591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0004002171,0.00004413956,0.0007647998,0.8639446,0.007407624,0.0002354515,0.0001252336,0.0002332347,0.0004834096,0.000297135,0.004115713,0.1219484],"study_design_scores_gemma":[0.0006567959,0.0006679156,0.009550743,0.7061033,0.1458052,0.002566976,0.0005970133,0.0002437533,0.0007237726,0.0009780426,0.131933,0.0001735233],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002719064,0.9994395,0.00004004013,0.00005263622,0.00003445613,0.00001826102,0.0000730739,0.000002031668,0.0000680392],"genre_scores_gemma":[0.002068964,0.9975223,0.0001126494,0.0001610966,0.0000303884,0.00001640212,0.00004679396,0.000001190964,0.00004012589],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005562672,"threshold_uncertainty_score":0.01181173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1640465031503143,"score_gpt":0.4801198568830462,"score_spread":0.3160733537327319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}