{"id":"W2616101171","doi":"10.1371/journal.ppat.1006372","title":"Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Mitacs; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Erasmus Medisch Centrum; Canadian Light Source","keywords":"ISG15; Biology; Deubiquitinating enzyme; Ubiquitin; Virology; Viral replication; Middle East respiratory syndrome coronavirus; Viral protein; Viral structural protein; Viral life cycle; Ebola virus; Antiviral drug; Virus; Viral entry; Gene; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563604,0.0004733751,0.0002128236,0.000155592,0.0001036412,0.0002681963,0.0002014526,0.0002250648,0.0004618147],"category_scores_gemma":[0.0001183054,0.000128268,0.0002149062,0.0001493751,0.0001288405,0.0001648132,0.000231743,0.0003135758,0.0001806551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002483568,"about_ca_system_score_gemma":0.0001356322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003169946,"about_ca_topic_score_gemma":0.0008634539,"domain_scores_codex":[0.9998553,0.00001447611,0.00001298442,0.00003436337,0.00004471134,0.00003818339],"domain_scores_gemma":[0.9999496,0.00001048171,0.00001560724,0.000007128791,0.000008293512,0.000008892805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000501291,0.00004569947,0.0001795464,0.00003217074,0.000008626575,0.00003263111,0.00001135897,0.0002770726,0.9946023,0.0001339082,0.00004785789,0.004578627],"study_design_scores_gemma":[0.000005808069,0.0001977508,0.0006743621,0.000001456609,0.000005668047,0.0001342872,0.000004317467,0.0008588979,0.9969631,0.00001477541,0.001136985,0.000002601977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817321,0.002131291,0.01299804,0.00005450166,0.00003329082,0.0000827984,0.0003386972,0.0001561428,0.00247323],"genre_scores_gemma":[0.9904192,0.001108717,0.005654219,0.00005322674,0.000008001027,0.00003796604,0.0004687275,0.00001897914,0.002230832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004733751,"threshold_uncertainty_score":0.001801968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829430878294,"score_gpt":0.2384604484229612,"score_spread":0.2201661396400212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}