{"id":"W2616101171","doi":"10.1371/journal.ppat.1006372","title":"Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Mitacs; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Erasmus Medisch Centrum; Canadian Light Source","keywords":"ISG15; Biology; Deubiquitinating enzyme; Ubiquitin; Virology; Viral replication; Middle East respiratory syndrome coronavirus; Viral protein; Viral structural protein; Viral life cycle; Ebola virus; Antiviral drug; Virus; Viral entry; Gene; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575348,0.0001690556,0.0001877693,0.0000327415,0.0001890393,0.00003601159,0.0001407587,0.0001621061,0.00001606097],"category_scores_gemma":[0.0002398282,0.0001687964,0.0000717753,0.00002846569,0.0001011084,0.000008509067,0.0001489367,0.00008310697,0.000006511047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000914718,"about_ca_system_score_gemma":0.00004330276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001219188,"about_ca_topic_score_gemma":0.000007392355,"domain_scores_codex":[0.9990371,0.00006052124,0.0001979174,0.0003418148,0.0001305759,0.0002320892],"domain_scores_gemma":[0.9991734,0.00001116917,0.0001806964,0.0004280284,0.0001099834,0.0000967317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005339959,0.0001007383,0.001890227,0.00003775397,0.00006244579,0.000006876621,0.00008283878,0.000001188888,0.9958122,0.00006382992,0.0003225442,0.001565918],"study_design_scores_gemma":[0.0005361321,0.0003143807,0.008065935,0.00003660486,0.00004318058,0.00001470608,0.00003158853,0.00004763548,0.9899479,0.000137255,0.0006274761,0.0001972461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965245,0.0006509734,0.0004410497,0.00005233418,0.00005179998,0.0002680734,0.0007463161,0.00001516327,0.001249767],"genre_scores_gemma":[0.9985934,0.0002561591,0.0006366274,0.0001102681,0.0001237328,0.00004147805,0.0001079324,0.00002812593,0.0001022864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006175708,"threshold_uncertainty_score":0.6883317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829430878294,"score_gpt":0.2384604484229612,"score_spread":0.2201661396400212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}