{"id":"W2616124434","doi":"10.3390/vaccines5020011","title":"The Effect of Physicochemical Modification on the Function of Antibodies Induced by Anti-Nicotine Vaccine in Mice","year":2017,"lang":"en","type":"article","venue":"Vaccines","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"","keywords":"Hapten; Conjugate; Diphtheria toxin; Nicotine; Immunogenicity; Chemistry; Adjuvant; Antibody; Immune system; Protein tertiary structure; Pharmacology; Stereochemistry; Immunology; Biochemistry; Toxin; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003725325,0.0001302552,0.0002598504,0.00003640737,0.0002728803,0.0000152057,0.0003921983,0.0001178697,0.00002555774],"category_scores_gemma":[0.000309548,0.00006617702,0.0000704097,0.00005910606,0.00004434637,0.0000704462,0.000071676,0.0001827213,0.00002033768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008149503,"about_ca_system_score_gemma":0.000007883915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001486518,"about_ca_topic_score_gemma":0.00001608906,"domain_scores_codex":[0.999249,0.0001435717,0.0002640855,0.000156752,0.00003177483,0.0001548045],"domain_scores_gemma":[0.9986935,0.0003773003,0.0003405483,0.0005320451,0.00005187703,0.000004713078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005301014,0.00006423884,0.003251478,0.000015757,0.00006025854,3.296886e-8,0.00004568247,0.000001338686,0.990697,0.0006978966,0.0009537153,0.003682453],"study_design_scores_gemma":[0.001044345,0.0004382597,0.1153704,0.000044276,0.00002539726,6.133161e-7,0.00004206742,0.00001164552,0.8824718,0.000106052,0.0003867942,0.0000583615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975809,0.000838498,0.00001241247,0.0007689543,0.0003853979,0.0002705972,0.00001180868,0.00001093332,0.000120437],"genre_scores_gemma":[0.9995707,0.0001650384,0.00000196951,0.0000167832,0.00002276829,0.00001869813,0.00002092058,0.000009297201,0.00017387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1121189,"threshold_uncertainty_score":0.269862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125237670801876,"score_gpt":0.2543052795639166,"score_spread":0.241781512483729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}