{"id":"W2616124434","doi":"10.3390/vaccines5020011","title":"The Effect of Physicochemical Modification on the Function of Antibodies Induced by Anti-Nicotine Vaccine in Mice","year":2017,"lang":"en","type":"article","venue":"Vaccines","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"","keywords":"Hapten; Conjugate; Diphtheria toxin; Nicotine; Immunogenicity; Chemistry; Adjuvant; Antibody; Immune system; Protein tertiary structure; Pharmacology; Stereochemistry; Immunology; Biochemistry; Toxin; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003688775,0.0005684816,0.0002680713,0.0004351761,0.0001166198,0.0002605524,0.0002873177,0.0006196942,0.000755905],"category_scores_gemma":[0.0002908056,0.0002487108,0.000312253,0.0001467777,0.0003297586,0.0003832678,0.0001540386,0.001010204,0.0002246622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002793406,"about_ca_system_score_gemma":0.0001735877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004019753,"about_ca_topic_score_gemma":0.0004216486,"domain_scores_codex":[0.9996573,0.00008558539,0.00002627037,0.00006482412,0.00006645094,0.00009963364],"domain_scores_gemma":[0.9996421,0.00008611981,0.000114192,0.00004379081,0.00004467922,0.00006906563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003850575,0.0001896951,0.0001403743,0.00001932754,0.000006830126,0.00001957307,0.00001394739,0.00008089148,0.9983882,0.00003735061,0.00001464262,0.0007042446],"study_design_scores_gemma":[0.00003026088,0.003449616,0.002033612,0.000004332896,0.00002463649,0.00006438507,0.000009914759,0.0005843851,0.9932815,0.00003522857,0.0004772775,0.000004769951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971892,0.0004759358,0.001158995,0.00006377348,0.00002809752,0.00004334805,0.0001519702,0.00005379339,0.0008349553],"genre_scores_gemma":[0.9955728,0.0005513467,0.001372584,0.00009997952,0.0000216213,0.00005879943,0.0003050621,0.00003068825,0.001987142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000755905,"threshold_uncertainty_score":0.002528787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125237670801876,"score_gpt":0.2543052795639166,"score_spread":0.241781512483729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}