{"id":"W2616221807","doi":"10.1152/jn.00083.2017","title":"In vivo optogenetic activation of Na<sub>v</sub>1.8<sup>+</sup> cutaneous nociceptors and their responses to natural stimuli","year":2017,"lang":"en","type":"article","venue":"Journal of Neurophysiology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute on Drug Abuse; Government of Canada","keywords":"Nociceptor; Optogenetics; Neuroscience; Stimulation; Channelrhodopsin; Chemistry; Electrophysiology; Nociception; Stimulus (psychology); Sodium channel; Receptive field; Biophysics; Biology; Sodium; Psychology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722626,0.0003648489,0.0002276592,0.0002011577,0.0001135853,0.0002911887,0.0003175424,0.0003008276,0.001668686],"category_scores_gemma":[0.0001159595,0.0002230954,0.0002343806,0.00009647686,0.0003112624,0.0002772411,0.0001674087,0.0006300831,0.0004198678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434633,"about_ca_system_score_gemma":0.0001527641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004445848,"about_ca_topic_score_gemma":0.0009117099,"domain_scores_codex":[0.9998372,0.00001156492,0.00001548657,0.00004691821,0.00003741673,0.0000513947],"domain_scores_gemma":[0.9998503,0.00002846853,0.00005455894,0.00002174135,0.00001405215,0.00003085898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005461318,0.00001232115,0.00005815955,0.0000144855,0.00000166038,0.0000120165,0.000004791949,0.00002555688,0.9993936,0.00003517527,0.00001274639,0.0003750248],"study_design_scores_gemma":[0.00001699183,0.0002062642,0.00346028,0.000005070788,0.000009596015,0.0001485365,0.00001948241,0.0007569231,0.9945223,0.00004198969,0.0008098222,0.000002719732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914283,0.0003673534,0.005777974,0.00007421963,0.00004054032,0.00006576449,0.0005091876,0.0001063964,0.001630108],"genre_scores_gemma":[0.9871586,0.0003603417,0.007361726,0.00007815123,0.00001331848,0.0001806167,0.0004270639,0.00007140378,0.004348778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668686,"threshold_uncertainty_score":0.005582333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03936620184362761,"score_gpt":0.3250290719179758,"score_spread":0.2856628700743482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}