{"id":"W2616231456","doi":"10.1002/gcc.22471","title":"<i>KIF11</i> silencing and inhibition induces chromosome instability that may contribute to cancer","year":2017,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"University of Manitoba; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Biology; Chromosome instability; Gene silencing; Genome instability; Instability; Chromosome; Cancer; Cancer research; Genetics; Cell biology; DNA; DNA damage; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001164626,0.0002409811,0.0001968403,0.0001812912,0.0001812964,0.0004119129,0.0001568487,0.0002892403,0.001802858],"category_scores_gemma":[0.0001118529,0.0001233327,0.000222018,0.0001303009,0.0002042781,0.000182027,0.0001615957,0.0004159824,0.0006448268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000457242,"about_ca_system_score_gemma":0.0002339589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009451007,"about_ca_topic_score_gemma":0.001596636,"domain_scores_codex":[0.999908,0.00001152395,0.00001004369,0.00002266222,0.00002230936,0.00002548336],"domain_scores_gemma":[0.9999362,0.00001379562,0.00002069709,0.00001154943,0.000007752115,0.000009981433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003645422,0.000009949401,0.0002078919,0.00003371943,0.000004604566,0.00003910582,0.000005343652,0.00004932524,0.9978371,0.0001767724,0.0001159994,0.001483767],"study_design_scores_gemma":[0.000004103985,0.0000638951,0.00555089,0.000006347509,0.00000925285,0.000315263,0.00001915662,0.0005545811,0.9868494,0.00006939161,0.00655339,0.000004281607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697767,0.006804288,0.01027998,0.0006540522,0.0001272774,0.00005661395,0.001421594,0.0005752984,0.01030418],"genre_scores_gemma":[0.9890618,0.002465643,0.002239747,0.0001123063,0.00001058161,0.00003818605,0.000776401,0.00004162086,0.005253788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802858,"threshold_uncertainty_score":0.006031156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654082882216765,"score_gpt":0.2765031822935295,"score_spread":0.2599623534713618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}