{"id":"W2616279709","doi":"10.1038/nature22370","title":"Haematopoietic stem and progenitor cells from human pluripotent stem cells","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":506,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Crohn's and Colitis Foundation; Howard Hughes Medical Institute","keywords":"Stem cell; Haematopoiesis; Induced pluripotent stem cell; Biology; Cell biology; Progenitor cell; Induced stem cells; Embryonic stem cell; Endothelial stem cell; Cellular differentiation; Adult stem cell; Morphogen; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003830759,0.0002336514,0.0001533454,0.000399599,0.0001906229,0.0004608259,0.0002949091,0.0003076785,0.004776252],"category_scores_gemma":[0.0001789368,0.0002525168,0.0002073826,0.0002256324,0.0002620254,0.0002086747,0.0003669226,0.0007697439,0.001801307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344667,"about_ca_system_score_gemma":0.0004197157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005590676,"about_ca_topic_score_gemma":0.001855895,"domain_scores_codex":[0.9998878,0.00001258107,0.00001152146,0.00001471752,0.00006272156,0.00001057445],"domain_scores_gemma":[0.9999324,0.00001594271,0.00001186423,0.00001073028,0.00001319401,0.00001578811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007410908,0.00001198438,0.0004242779,0.00009572235,0.000009676543,0.0001617276,0.0000436853,0.0001706925,0.9816718,0.0038665,0.0009139816,0.01255593],"study_design_scores_gemma":[0.0000763931,0.0001109082,0.005088645,0.0000417091,0.00004436114,0.0006205757,0.00004131858,0.0008031083,0.9197438,0.001534036,0.07188111,0.00001393609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.695715,0.01435979,0.1753797,0.003234745,0.0009570218,0.0009370678,0.01032938,0.001447033,0.09764035],"genre_scores_gemma":[0.8532898,0.007091568,0.07117616,0.0008635988,0.00016234,0.0002724077,0.008434234,0.0002518143,0.05845801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004776252,"threshold_uncertainty_score":0.0159781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232480066607121,"score_gpt":0.2920874889437547,"score_spread":0.2797626882776835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}