{"id":"W2616394381","doi":"10.1182/blood.v128.22.977.977","title":"Selinexor in Combination with Bortezomib and Dexamethasone (SdB) Demonstrates Significant Activity in Patients with Refractory Multiple Myeloma (MM) Including Proteasome-Inhibitor Refractory Patients: Results of the Phase I Stomp Trial","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; Queen Elizabeth II Health Sciences Centre; Hôpital Maisonneuve-Rosemont; CancerCare Manitoba; Ottawa Hospital; Juravinski Cancer Centre; Institute of Cancer Research; University of Manitoba; Princess Margaret Cancer Centre; University of Calgary; Vancouver General Hospital; Memorial University of Newfoundland; McGill University Health Centre","funders":"","keywords":"Bortezomib; Tolerability; Refractory (planetary science); Medicine; Dexamethasone; Proteasome inhibitor; Internal medicine; Phases of clinical research; Pharmacology; Multiple myeloma; Oncology; Clinical trial; Gastroenterology; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002021297,0.0001588181,0.0001835165,0.00006767898,0.00005112875,0.00001024167,0.00008568382,0.0001373379,0.000001233336],"category_scores_gemma":[0.0003066394,0.00008867926,0.00002580499,0.0001340072,0.0001102465,0.00002674805,0.00005500422,0.0001253174,1.782093e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002984306,"about_ca_system_score_gemma":0.0000749083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004334002,"about_ca_topic_score_gemma":0.0001710792,"domain_scores_codex":[0.9988594,0.0001634342,0.0002643141,0.0003462984,0.0001993339,0.0001672435],"domain_scores_gemma":[0.9992116,0.00005788386,0.0002960796,0.0002605777,0.0001305595,0.00004327807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05756059,0.003680994,0.3831754,0.0000250215,0.00005482187,0.000001379238,0.0001006724,0.000001708259,0.5334546,0.000001528216,0.00002114505,0.0219221],"study_design_scores_gemma":[0.1746442,0.006592531,0.6030793,0.0001312698,0.00003566759,6.164147e-7,0.00003772412,0.000008961591,0.215001,0.000007919507,0.0002592469,0.0002015231],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987394,0.00002192477,0.0000338069,0.00003430038,0.00007187529,0.001000526,0.00007018063,0.000006718531,0.00002125053],"genre_scores_gemma":[0.9995955,0.0000116895,0.0002231923,0.00001128944,0.00005705031,0.0000327029,0.00003763429,0.00001991418,0.00001101479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3184536,"threshold_uncertainty_score":0.3616235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008298695547919364,"score_gpt":0.2210101915872341,"score_spread":0.2127114960393147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}