{"id":"W2616394381","doi":"10.1182/blood.v128.22.977.977","title":"Selinexor in Combination with Bortezomib and Dexamethasone (SdB) Demonstrates Significant Activity in Patients with Refractory Multiple Myeloma (MM) Including Proteasome-Inhibitor Refractory Patients: Results of the Phase I Stomp Trial","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; Queen Elizabeth II Health Sciences Centre; Hôpital Maisonneuve-Rosemont; CancerCare Manitoba; Ottawa Hospital; Juravinski Cancer Centre; Institute of Cancer Research; University of Manitoba; Princess Margaret Cancer Centre; University of Calgary; Vancouver General Hospital; Memorial University of Newfoundland; McGill University Health Centre","funders":"","keywords":"Bortezomib; Tolerability; Refractory (planetary science); Medicine; Dexamethasone; Proteasome inhibitor; Internal medicine; Phases of clinical research; Pharmacology; Multiple myeloma; Oncology; Clinical trial; Gastroenterology; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001542095,0.0008025568,0.001404828,0.0002299069,0.0002314643,0.0007339917,0.0004172171,0.0005861025,0.00204718],"category_scores_gemma":[0.0006309944,0.0002722833,0.0009453447,0.0002459309,0.0004839612,0.0005398492,0.000293632,0.002035534,0.0003275215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005649983,"about_ca_system_score_gemma":0.0006948519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003954945,"about_ca_topic_score_gemma":0.001609573,"domain_scores_codex":[0.9996513,0.0001974874,0.00002154109,0.00005059766,0.00003192506,0.00004704191],"domain_scores_gemma":[0.9995267,0.0001143647,0.00009950754,0.00002742082,0.00002382598,0.000208179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7248078,0.0339457,0.01419275,0.0009451376,0.00187739,0.0004419195,0.00034967,0.002556051,0.04654117,0.0003216999,0.005197586,0.1688232],"study_design_scores_gemma":[0.4997148,0.4607884,0.02800989,0.00006959587,0.0007167093,0.0005126139,0.00007769729,0.001391885,0.004679449,0.000203187,0.003810702,0.00002501011],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945208,0.002319406,0.0002106364,0.0004373254,0.00005507664,0.0005280082,0.0005756554,0.00004456875,0.001308537],"genre_scores_gemma":[0.9937407,0.001679774,0.0008121711,0.0004853223,0.0001010651,0.0004812113,0.00115491,0.00001474485,0.001530076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00204718,"threshold_uncertainty_score":0.008155465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008298695547919364,"score_gpt":0.2210101915872341,"score_spread":0.2127114960393147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}