{"id":"W2616420862","doi":"10.1038/oncsis.2017.30","title":"Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors","year":2017,"lang":"en","type":"article","venue":"Oncogenesis","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; National Institute for Health and Care Research; Ontario Genomics; Pfizer","keywords":"Epigenetics; Cancer research; Biology; Histone; Histone methyltransferase; Propidium iodide; DNA methylation; Apoptosis; Bromodomain; Cell cycle; Cancer epigenetics; Cyclin D1; Molecular biology; Genetics; Gene expression; Programmed cell death; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803875,0.0003887269,0.0002933474,0.0004298247,0.00014809,0.0003348712,0.0002609593,0.0004615502,0.003492384],"category_scores_gemma":[0.00009986648,0.0001194987,0.0003364772,0.0002751345,0.0001621273,0.0002841441,0.0001833454,0.001086147,0.000756788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003019805,"about_ca_system_score_gemma":0.000193967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395973,"about_ca_topic_score_gemma":0.002154825,"domain_scores_codex":[0.9999484,0.00000842397,0.000004065756,0.0000104854,0.00001609397,0.00001254648],"domain_scores_gemma":[0.9999537,0.000008297416,0.00001410873,0.000002921402,0.000009931256,0.00001111903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001293567,0.001034718,0.002001773,0.001405472,0.0001064557,0.0005802604,0.00008452341,0.001217969,0.5952902,0.004152263,0.005955377,0.3868775],"study_design_scores_gemma":[0.00172413,0.01561085,0.02573854,0.000412711,0.0003592027,0.004780134,0.0001429782,0.003241999,0.5639153,0.002389899,0.3816022,0.00008208305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4890001,0.4353462,0.01910846,0.006871473,0.001121898,0.0009154007,0.00289523,0.0008369459,0.04390437],"genre_scores_gemma":[0.7291526,0.2206579,0.01163369,0.002115502,0.0004366932,0.0004355457,0.002631366,0.00005327551,0.0328834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003492384,"threshold_uncertainty_score":0.01168317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186299800539821,"score_gpt":0.3146660545490026,"score_spread":0.2960360744950205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}