{"id":"W2616420862","doi":"10.1038/oncsis.2017.30","title":"Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors","year":2017,"lang":"en","type":"article","venue":"Oncogenesis","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; National Institute for Health and Care Research; Ontario Genomics; Pfizer","keywords":"Epigenetics; Cancer research; Biology; Histone; Histone methyltransferase; Propidium iodide; DNA methylation; Apoptosis; Bromodomain; Cell cycle; Cancer epigenetics; Cyclin D1; Molecular biology; Genetics; Gene expression; Programmed cell death; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001348516,0.0003165232,0.0006079637,0.0001586043,0.0007134776,0.0001581562,0.000267106,0.00001160383,0.00004206082],"category_scores_gemma":[0.001099196,0.0002781132,0.0002128467,0.00007871279,0.0002836949,0.000192229,0.0002987949,0.0001616579,0.00001343131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006306297,"about_ca_system_score_gemma":0.000158928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004287832,"about_ca_topic_score_gemma":0.00004944409,"domain_scores_codex":[0.9974846,0.00008761467,0.0004544026,0.0007396148,0.0005014888,0.0007322644],"domain_scores_gemma":[0.9979793,0.0002074778,0.0002710544,0.0009824543,0.0001184171,0.0004413065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003236782,0.0007416564,0.1813841,0.00150681,0.0003205445,0.01882481,0.0002053927,0.00008238336,0.4090234,0.000146727,0.001397103,0.3831303],"study_design_scores_gemma":[0.01151257,0.003371022,0.1606064,0.0004909293,0.0005954958,0.007787502,0.0004489849,0.001596887,0.7997805,0.0007024349,0.01227262,0.0008346091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938806,0.0007168031,0.00004942486,0.002440947,0.0002785318,0.001266445,0.00004190557,0.00009210905,0.001233276],"genre_scores_gemma":[0.9932692,0.0003421676,0.001440747,0.0001128814,0.0008114328,0.000253042,0.00002039431,0.00009026393,0.003659881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3907571,"threshold_uncertainty_score":0.9999671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186299800539821,"score_gpt":0.3146660545490026,"score_spread":0.2960360744950205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}