{"id":"W2616665343","doi":"10.1007/s40262-017-0544-2","title":"Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide","year":2017,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Morphine; Medicine; Pharmacokinetics; Glucuronidation; NONMEM; Population; Volume of distribution; Body mass index; Anesthesia; Pharmacology; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00182301,0.0005039901,0.001068743,0.0001625707,0.000273484,0.0000565044,0.001149458,0.0002045477,0.0002428465],"category_scores_gemma":[0.002853386,0.0003694331,0.0003639761,0.0002229945,0.001691792,0.0001671978,0.0007565709,0.001012179,0.00004509629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000302236,"about_ca_system_score_gemma":0.00009933688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000754968,"about_ca_topic_score_gemma":0.000004275702,"domain_scores_codex":[0.9961194,0.0002271991,0.001606976,0.0006851251,0.0008227795,0.0005385536],"domain_scores_gemma":[0.9947904,0.001290526,0.001262794,0.001814645,0.0004344564,0.0004072259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001649291,0.002440565,0.8947536,0.001022176,0.0009028199,0.0002352702,0.0001867784,0.002696204,0.05018469,0.002493981,0.03704294,0.006391684],"study_design_scores_gemma":[0.005924211,0.0008548039,0.9358187,0.0003646797,0.001116271,0.000007558293,0.0000235944,0.01240397,0.02720748,0.0009934403,0.01486393,0.0004213378],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880105,0.0004939127,0.0001085223,0.006787307,0.0004684486,0.001103116,0.00006646392,0.00006510726,0.002896633],"genre_scores_gemma":[0.9884979,0.005923609,0.0007826544,0.003092011,0.0006033356,0.00002187033,0.00001583196,0.00006774288,0.0009950732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04106513,"threshold_uncertainty_score":0.9998758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06270001594124372,"score_gpt":0.3873581527800608,"score_spread":0.3246581368388171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}