{"id":"W2616677922","doi":"10.3389/fnmol.2017.00125","title":"Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid","year":2017,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences","funders":"Natural Sciences and Engineering Research Council of Canada; Russian Foundation for Basic Research; Agence Nationale de la Recherche","keywords":"Homomeric; Glycine receptor; Niflumic acid; Chemistry; Chloride channel; Biophysics; Glycine; Voltage clamp; Ion channel; Strychnine; Patch clamp; Pharmacology; Protein subunit; Membrane potential; Stereochemistry; Amino acid; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138542,0.0002648217,0.0002411891,0.0001182534,0.00008621118,0.0001819715,0.0003170711,0.0002258104,0.0004566932],"category_scores_gemma":[0.0001744026,0.00009119871,0.0003072713,0.00008966865,0.0001627884,0.0001614648,0.0001316034,0.000275727,0.0001552508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002587297,"about_ca_system_score_gemma":0.0001013763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007479681,"about_ca_topic_score_gemma":0.000716529,"domain_scores_codex":[0.9998838,0.00002192179,0.00001366167,0.00001949802,0.00002709176,0.00003397948],"domain_scores_gemma":[0.9999354,0.00001937869,0.0000209414,0.000007190667,0.000006434618,0.00001056613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008018376,0.00001237774,0.00006810353,0.0000192156,0.000004806641,0.00002600178,0.000007407391,0.00002726401,0.9991421,0.00003125753,0.00001332289,0.0005680674],"study_design_scores_gemma":[0.00002083215,0.0003197502,0.002608493,0.000004085621,0.00001228525,0.0001779191,0.0000101408,0.001202018,0.9947196,0.00001879335,0.0009020931,0.00000378016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969433,0.0008867173,0.001242995,0.00004696846,0.00001544506,0.0000119611,0.00009461957,0.00004520783,0.0007127845],"genre_scores_gemma":[0.9971923,0.0007174568,0.001410734,0.00003284354,0.00000919943,0.00001741518,0.0001676352,0.00001222811,0.000440208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007479681,"threshold_uncertainty_score":0.001877189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007311901597542715,"score_gpt":0.2482345656666146,"score_spread":0.2409226640690718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}