{"id":"W2616677922","doi":"10.3389/fnmol.2017.00125","title":"Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid","year":2017,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences","funders":"Natural Sciences and Engineering Research Council of Canada; Russian Foundation for Basic Research; Agence Nationale de la Recherche","keywords":"Homomeric; Glycine receptor; Niflumic acid; Chemistry; Chloride channel; Biophysics; Glycine; Voltage clamp; Ion channel; Strychnine; Patch clamp; Pharmacology; Protein subunit; Membrane potential; Stereochemistry; Amino acid; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003268684,0.0002099645,0.0002512566,0.00008466584,0.000170976,0.00006119991,0.0007575902,0.0001360484,0.000006654142],"category_scores_gemma":[0.0004704377,0.0002213003,0.00007533711,0.0001115085,0.0004274043,0.00002094523,0.0004078228,0.0001718694,0.000004291809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002753497,"about_ca_system_score_gemma":0.00006486914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003184611,"about_ca_topic_score_gemma":0.000003669625,"domain_scores_codex":[0.9982038,0.00007573945,0.0003246088,0.0006749376,0.0003418726,0.000379088],"domain_scores_gemma":[0.998655,0.000002625801,0.0003021975,0.0008822085,0.00005644516,0.0001015556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004227118,0.000118876,0.005690094,0.00001119837,0.000004879441,0.000003455697,0.00001919229,0.00005080412,0.9811087,0.000009756552,0.01189572,0.001045037],"study_design_scores_gemma":[0.0007893114,0.0002774348,0.0003751429,0.0000193552,0.000007349285,0.000005817699,0.0000365401,0.0001732298,0.9891349,0.0000344663,0.008933351,0.000213116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9178705,0.0007162164,0.07811565,0.0002162123,0.002258705,0.0003818035,0.00005806232,0.00001361866,0.0003692933],"genre_scores_gemma":[0.9970306,0.0002881934,0.001679905,0.0002889784,0.00006906392,0.00002368217,0.00004239432,0.00003085089,0.0005463639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07916012,"threshold_uncertainty_score":0.9024364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007311901597542715,"score_gpt":0.2482345656666146,"score_spread":0.2409226640690718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}