{"id":"W2616704730","doi":"10.1007/978-3-319-53889-1_1","title":"MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome","year":2017,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Chromatin; Rett syndrome; Epigenetics; Histone; Biology; Cell biology; Chromatin remodeling; Chromodomain; Nucleosome; Genetics; Neuroscience; DNA; RNA; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004089536,0.0008044396,0.001131434,0.0009602555,0.0001689201,0.0007586401,0.0008937207,0.0009322203,0.001777439],"category_scores_gemma":[0.0004594344,0.0002159082,0.0002556849,0.0009820515,0.0003981345,0.0007135471,0.0006612165,0.001247206,0.001074004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005507037,"about_ca_system_score_gemma":0.0009067105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009981946,"about_ca_topic_score_gemma":0.001979809,"domain_scores_codex":[0.9998808,0.00001225924,0.00001744559,0.00002273063,0.00005107679,0.00001560975],"domain_scores_gemma":[0.9998856,0.00004079314,0.00002356234,0.000003393499,0.00002868686,0.00001792525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000187962,0.00003261192,0.0003871718,0.01124264,0.0001419947,0.0007122211,0.00004871151,0.0004756548,0.00721907,0.003058442,0.03380394,0.9426895],"study_design_scores_gemma":[0.00005227836,0.0000638324,0.001517876,0.001804668,0.0002285955,0.002491397,0.00006003973,0.0001320446,0.002401984,0.001788866,0.9894311,0.00002725969],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001901514,0.9986476,0.000144936,0.0002405929,0.0001669975,0.000002958601,0.00002630086,0.000007836706,0.0005725129],"genre_scores_gemma":[0.001238846,0.9973553,0.0001973684,0.0002160346,0.0002163888,0.000005270074,0.00007006878,0.000001830022,0.0006989323],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001777439,"threshold_uncertainty_score":0.005946159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04725421017785097,"score_gpt":0.3703314547107338,"score_spread":0.3230772445328828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}