{"id":"W2616853239","doi":"10.1146/annurev-virology-101416-041616","title":"The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs","year":2017,"lang":"en","type":"review","venue":"Annual Review of Virology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"CRISPR; Biology; Trans-activating crRNA; Archaea; Plasmid; Genetics; Function (biology); Computational biology; Gene; DNA; Genome editing; RNA; Bacteriophage; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004056462,0.0002847077,0.001260042,0.0000373964,0.00007456384,0.000007495213,0.0004490705,0.0002530343,0.000005517578],"category_scores_gemma":[0.0003182499,0.000171953,0.0006369749,0.00004244946,0.000243288,0.000004601469,0.000303793,0.0001438497,0.000002102076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009049392,"about_ca_system_score_gemma":0.0002081573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002207735,"about_ca_topic_score_gemma":0.000003551168,"domain_scores_codex":[0.9986588,0.0001445312,0.0005758301,0.0002981294,0.0000994597,0.0002231854],"domain_scores_gemma":[0.9985076,0.00006603266,0.0005381751,0.0007513607,0.00008618351,0.0000506713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001464549,0.00004410987,0.00001119022,0.05231773,0.0007608435,0.000004020832,0.000008143853,0.00000381944,0.0006026036,0.0004444732,0.005995141,0.9397933],"study_design_scores_gemma":[0.00007540435,0.0004367812,0.0001558922,0.008352046,0.0004418617,0.0001006027,0.000003235713,8.420601e-7,0.00004094954,0.0000608403,0.9901634,0.0001681145],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005037558,0.9985402,0.0004089934,0.00002999972,0.0001386005,0.0004017889,0.0003123157,0.000002262303,0.0001155167],"genre_scores_gemma":[0.0004514377,0.9989879,0.0001051535,0.00002549344,0.00008631707,0.00002932246,0.0001478065,0.00002657547,0.0001399779],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9841683,"threshold_uncertainty_score":0.7012039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671879033947082,"score_gpt":0.3972748609744031,"score_spread":0.3805560706349323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}