{"id":"W2617020095","doi":"10.1002/jmv.24867","title":"MxA is a positive regulator of type I IFN signaling in HCV infection","year":2017,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Chinese Academy of Medical Sciences; National Natural Science Foundation of China","keywords":"Biology; Hepatitis C virus; Interferon; STAT1; Virology; JAK-STAT signaling pathway; Signal transduction; Gene; Reporter gene; Regulator; Interferon-stimulated gene; Plasmid; stat; Western blot; Luciferase; Gene expression; Molecular biology; Transfection; Virus; STAT3; Receptor; Cell biology; Innate immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001911504,0.0002743503,0.0002517574,0.0002403835,0.0003348888,0.0003314849,0.0001016611,0.0002795044,0.001474515],"category_scores_gemma":[0.00009162339,0.0001525263,0.0003600784,0.0001233214,0.0001855176,0.0001901326,0.0002597723,0.0005687385,0.000338992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002725166,"about_ca_system_score_gemma":0.0002115123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003410413,"about_ca_topic_score_gemma":0.0003150279,"domain_scores_codex":[0.9998754,0.00002461176,0.00001247746,0.00002617108,0.00003564325,0.00002557025],"domain_scores_gemma":[0.9999338,0.000007666709,0.00002492155,0.000004526587,0.00001056658,0.00001843847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002742545,0.00003303589,0.00263614,0.0001698092,0.00001869068,0.0002560146,0.00003964995,0.0001491828,0.9904444,0.0004360917,0.0003493824,0.005193403],"study_design_scores_gemma":[0.00009529167,0.0007084701,0.1105284,0.0001686567,0.0001569581,0.002659558,0.0001648222,0.006490502,0.8407778,0.001005663,0.03720081,0.00004311367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331431,0.04187876,0.01185688,0.0009194547,0.0003214586,0.0001540151,0.001883705,0.0004239407,0.00941861],"genre_scores_gemma":[0.9873647,0.005081291,0.002550565,0.0001773098,0.00005699667,0.00006899262,0.0009431014,0.00001757759,0.003739552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474515,"threshold_uncertainty_score":0.004932821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04808955509273804,"score_gpt":0.418602429132793,"score_spread":0.370512874040055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}