{"id":"W2617210882","doi":"10.1038/s41598-017-03165-2","title":"Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Institute of Genetics; National Institute of General Medical Sciences; National Natural Science Foundation of China","keywords":"Smoothened; Hedgehog; Hedgehog signaling pathway; Signal transduction; Cell biology; Gene knockdown; Biology; Phosphorylation; Protein kinase A; Messenger RNA; Kinase; Transcription factor; G protein-coupled receptor; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001572171,0.0003168017,0.0003102421,0.00007830031,0.001937221,0.000696654,0.0004432343,0.0001932797,0.00001707942],"category_scores_gemma":[0.0009323542,0.0003010777,0.0001788932,0.0001070529,0.0006787123,0.00003192754,0.0005390214,0.0001652424,0.00001710087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004066679,"about_ca_system_score_gemma":0.0002389352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551488,"about_ca_topic_score_gemma":0.00009486244,"domain_scores_codex":[0.9970468,0.00008562548,0.0004306715,0.001391294,0.0004294527,0.0006161887],"domain_scores_gemma":[0.9965468,0.000009834465,0.0006798524,0.00234451,0.0002272714,0.000191717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001746315,0.00007665459,0.002654817,0.00004232628,0.00004947434,0.0002299558,0.0001631368,0.00000939986,0.9852978,0.000005047548,0.008004682,0.00344926],"study_design_scores_gemma":[0.00017422,0.00005089323,0.001523089,0.00009102124,0.00001104445,0.0000787238,0.00006224377,0.00002945794,0.9360089,0.0002776672,0.06133472,0.0003579875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937351,0.001122638,0.0002826441,0.0001751707,0.002429429,0.0005093697,0.00002422572,0.00005674606,0.001664681],"genre_scores_gemma":[0.9891999,0.0000103739,0.0002824777,0.00002579681,0.0002617861,0.00007333671,0.00008670021,0.00004096437,0.01001868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05333003,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993807305183334,"score_gpt":0.2571611294101805,"score_spread":0.2372230563583472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}