{"id":"W2617220693","doi":"10.1242/dev.146050","title":"Dynamic regulation of VEGF-inducible genes by an ERK-ERG-p300 transcriptional network","year":2017,"lang":"en","type":"article","venue":"Development","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Hospital for Sick Children; Heart and Stroke Foundation; University of Toronto; University Health Network","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Center for Research Resources; American Heart Association","keywords":"Biology; Enhancer; Chromatin immunoprecipitation; MAPK/ERK pathway; Transcription factor; Angiogenesis; Cell biology; ETS transcription factor family; Sprouting angiogenesis; Enhancer RNAs; Vascular endothelial growth factor; Notch signaling pathway; Regulation of gene expression; Activator (genetics); Promoter; Gene expression; Signal transduction; Genetics; Gene; Neovascularization; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435454,0.0001973647,0.0001889442,0.0003112291,0.0001732238,0.0002813736,0.0002519704,0.0001439326,0.0008960172],"category_scores_gemma":[0.000125257,0.0001738197,0.0001892296,0.000192986,0.000229954,0.0002797849,0.0003130307,0.0002669379,0.0004576294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005583498,"about_ca_system_score_gemma":0.0003235969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007833634,"about_ca_topic_score_gemma":0.001084133,"domain_scores_codex":[0.9998641,0.00001404183,0.000006240883,0.00004779334,0.00003820293,0.00002954859],"domain_scores_gemma":[0.9999275,0.00001080061,0.00001509107,0.000006388933,0.0000209378,0.00001912682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009588089,0.00002662902,0.001114623,0.00003791459,0.000005415868,0.0001111128,0.00002396944,0.0004009794,0.9928535,0.0006728195,0.00009768939,0.004559496],"study_design_scores_gemma":[0.00007278988,0.0002765448,0.1127329,0.00003270731,0.0000560998,0.001127013,0.0002391888,0.02793396,0.8434553,0.003170983,0.01086135,0.0000411468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697309,0.001806438,0.02249116,0.0002229155,0.00002089496,0.0000560578,0.0008374691,0.0002813214,0.004552863],"genre_scores_gemma":[0.9912793,0.0004907789,0.004893789,0.00005527232,0.000007382465,0.0000352816,0.0008174556,0.00001763389,0.002403076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008960172,"threshold_uncertainty_score":0.004051089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677797357800252,"score_gpt":0.2676380636658937,"score_spread":0.2508600900878912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}