{"id":"W2617220693","doi":"10.1242/dev.146050","title":"Dynamic regulation of VEGF-inducible genes by an ERK-ERG-p300 transcriptional network","year":2017,"lang":"en","type":"article","venue":"Development","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Hospital for Sick Children; Heart and Stroke Foundation; University of Toronto; University Health Network","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Center for Research Resources; American Heart Association","keywords":"Biology; Enhancer; Chromatin immunoprecipitation; MAPK/ERK pathway; Transcription factor; Angiogenesis; Cell biology; ETS transcription factor family; Sprouting angiogenesis; Enhancer RNAs; Vascular endothelial growth factor; Notch signaling pathway; Regulation of gene expression; Activator (genetics); Promoter; Gene expression; Signal transduction; Genetics; Gene; Neovascularization; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600657,0.0001067671,0.0001063859,0.00001481292,0.0002287139,0.00002296758,0.0002066288,0.0001044686,0.00005125406],"category_scores_gemma":[0.000005212547,0.0001039051,0.00005147898,0.00002120071,0.00005194224,0.000007145407,0.00004190523,0.00002351257,0.000004829097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002229632,"about_ca_system_score_gemma":0.0001245344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001440318,"about_ca_topic_score_gemma":0.00007168223,"domain_scores_codex":[0.9992434,0.00001681272,0.0001904488,0.0002517184,0.0001315703,0.0001660577],"domain_scores_gemma":[0.9994146,0.000001617345,0.0001227827,0.0003403165,0.0000683267,0.00005240105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005484751,0.00005845995,0.01056786,0.00001701603,0.00007884657,3.725733e-7,0.00006378932,0.0003369377,0.9411225,0.0001335125,0.003457369,0.04410848],"study_design_scores_gemma":[0.0003724051,0.00007958611,0.3742355,0.00002433088,0.00001324463,0.000002716414,0.00001692017,0.0002073489,0.3795124,0.0001100429,0.2451985,0.0002270179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916065,0.002472524,0.004643861,0.0001348897,0.0002764954,0.0001036569,0.0000168919,0.000006684101,0.000738471],"genre_scores_gemma":[0.9909615,0.0003086296,0.006491346,0.00006805404,0.0001247916,0.00002415066,0.0003774201,0.00001575611,0.001628383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5616102,"threshold_uncertainty_score":0.4237128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677797357800252,"score_gpt":0.2676380636658937,"score_spread":0.2508600900878912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}