{"id":"W2617245115","doi":"10.1038/leu.2017.162","title":"PPAR-delta modulates membrane cholesterol and cytokine signaling in malignant B cells","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; St. Michael's Hospital; Toronto General Hospital; University of Toronto; Sunnybrook Hospital","funders":"Canadian Institutes of Health Research","keywords":"Signal transduction; Peroxisome proliferator-activated receptor delta; Biology; Autocrine signalling; STAT protein; Cancer research; Janus kinase 2; Cytokine; Cell biology; Janus kinase; Peroxisome proliferator-activated receptor; Endocrinology; Internal medicine; Receptor; Transcription factor; Nuclear receptor; Immunology; STAT3; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626457,0.000200831,0.0002026921,0.00004952649,0.0001540115,0.0001089557,0.0003044733,0.000230962,0.00001735473],"category_scores_gemma":[0.00005169941,0.0001865515,0.00004426881,0.00003252586,0.0001109271,0.00001492467,0.000214894,0.0001593786,0.00001005521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005555541,"about_ca_system_score_gemma":0.00007328546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000211785,"about_ca_topic_score_gemma":0.00007279623,"domain_scores_codex":[0.9989036,0.00003972451,0.0002103488,0.0004328465,0.0001043792,0.0003090995],"domain_scores_gemma":[0.999205,0.000008098985,0.0001224071,0.0005265905,0.0000329081,0.0001050035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005426697,0.00001732107,0.01028352,0.00002250857,0.00002512002,0.000009166514,0.00004160295,0.0003360792,0.9880577,0.000006379516,0.0000771296,0.001069171],"study_design_scores_gemma":[0.0009794421,0.00007378039,0.002512194,0.0000497585,0.0000084388,0.00001291252,0.00001969298,0.0004007867,0.9935591,0.00003098533,0.002123422,0.0002295441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989799,0.0002240448,0.00004023709,0.00008954628,0.0001419714,0.0001555608,0.00001656006,0.00001409538,0.0003380335],"genre_scores_gemma":[0.9987572,0.0002485634,0.0002910938,0.0001624389,0.0001768083,0.00001951728,0.00003613032,0.00003312151,0.0002750694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007771322,"threshold_uncertainty_score":0.760735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114539835963184,"score_gpt":0.2420906343519165,"score_spread":0.2309452359922847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}