{"id":"W2617316722","doi":"10.2337/db16-1253","title":"An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":816,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; H. Lundbeck A/S; Novo Nordisk Foundation Center for Basic Metabolic Research; Universität Ulm; National Center for Research Resources; Diabetesliitto; Rheinische Friedrich-Wilhelms-Universität Bonn; Svenska Kulturfonden; Copenhagen Graduate School for Nanoscience and Nanotechnology; Sydäntutkimussäätiö; Medizinischen Hochschule Hannover; Broad Institute; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Horizon 2020 Framework Programme; Vetenskapsrådet; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Genome Canada; Novo Nordisk; Alfred Benzon Foundation; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; University of Exeter; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Samfundet Folkhälsan; Päivikki ja Sakari Sohlbergin Säätiö; European Regional Development Fund; Terveyden ja hyvinvoinnin laitos; Academy of Finland; Eesti Teadusagentuur; Kela; Minerva Foundation; Institut National de la Santé et de la Recherche Médicale; European Foundation for the Study of Diabetes; University of Oxford; Queen Mary University of London; Folkhälsanin Tutkimussäätiö; National Institute for Health and Care Research; Centre of Excellence for Environmental Decisions, Australian Research Council; Lee Kong Chian School of Medicine, Nanyang Technological University; Johns Hopkins University; National Heart, Lung, and Blood Institute; Nanyang Technological University; Novo Nordisk Fonden; Università degli Studi di Ferrara; American Heart Association; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; Massachusetts Institute of Technology; School of Medicine, Boston University; Helsingin Yliopisto; Steno Diabetes Center Copenhagen; National Cancer Institute; Lundbeckfonden; University College London; Wellcome Trust; Pfizer; Medical Research Council; Incyte; Foundation for Cardiovascular Research; British Heart Foundation; Brigham and Women's Hospital; Amgen; National Institute of Diabetes and Digestive and Kidney Diseases; Helsingin ja Uudenmaan Sairaanhoitopiiri; Imperial College London; National Human Genome Research Institute; Danmarks Frie Forskningsfond; Andrea and Charles Bronfman Philanthropies","keywords":"Genome-wide association study; Imputation (statistics); Biology; Genetic association; Type 2 diabetes; Single-nucleotide polymorphism; Genetics; Haplotype; 1000 Genomes Project; Population stratification; Quantitative trait locus; Locus (genetics); Allele frequency; Allele; Expression quantitative trait loci; Computational biology; Gene; Diabetes mellitus; Genotype; Endocrinology; Missing data","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003637003,0.0004645649,0.0009603396,0.001415329,0.0006562249,0.0008032928,0.0004673302,0.0006089706,0.001882974],"category_scores_gemma":[0.004838214,0.0002923462,0.001254165,0.003670083,0.0002435487,0.0003560465,0.0008162203,0.0005146217,0.0001952112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373914,"about_ca_system_score_gemma":0.0002650956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005674461,"about_ca_topic_score_gemma":0.006275143,"domain_scores_codex":[0.9968412,0.001463895,0.0002897811,0.0009663304,0.0002788292,0.000159976],"domain_scores_gemma":[0.9982684,0.0007037882,0.0002040236,0.0004401131,0.0002136667,0.0001701876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001349117,0.000079189,0.9769738,0.00008819078,0.003100438,0.001048932,0.0004026922,0.0004371787,0.005505111,0.0002414595,0.0006666446,0.01010715],"study_design_scores_gemma":[0.00006681986,0.00006951665,0.9969566,0.00001380076,0.0006716895,0.0005244763,0.00007472458,0.0002641381,0.0001755623,0.0001272065,0.001047,0.000008465008],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992712,0.001633963,0.002095738,0.0001246403,0.00003261525,0.00002009505,0.002311122,0.00002842551,0.001041323],"genre_scores_gemma":[0.9952224,0.0005623389,0.001550289,0.000127335,0.00003863338,0.00003063167,0.002157657,0.00001769641,0.000292918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005674461,"threshold_uncertainty_score":0.01923454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504084251361666,"score_gpt":0.2726777472123849,"score_spread":0.2576369046987682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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