{"id":"W2617328341","doi":"10.1097/ccm.0000000000002520","title":"Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis","year":2017,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Autophagy; Medicine; Atrophy; Sepsis; Perforation; Muscle atrophy; Diaphragm (acoustics); Tibialis anterior muscle; Skeletal muscle; Internal medicine; Pathology; Biology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006303191,0.0004899797,0.0006040325,0.0002782503,0.0001875884,0.0002133362,0.0001671425,0.0003759017,0.0009316208],"category_scores_gemma":[0.0002855188,0.0002009313,0.0003276649,0.0001845639,0.0005018557,0.0002828398,0.0003161532,0.0005720232,0.0001099118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144794,"about_ca_system_score_gemma":0.0002756281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001132006,"about_ca_topic_score_gemma":0.0002485446,"domain_scores_codex":[0.9995412,0.0001345892,0.0000525596,0.00009136457,0.00008307169,0.0000973468],"domain_scores_gemma":[0.9996465,0.00003392411,0.0001632931,0.00002001618,0.00003887187,0.00009734723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01303001,0.0003259704,0.002822749,0.0003167786,0.00003467207,0.0001296699,0.00003587274,0.0001431644,0.9784068,0.00003921504,0.00004238079,0.004672705],"study_design_scores_gemma":[0.001371865,0.06607918,0.263296,0.0001651674,0.0002676513,0.00120333,0.0002989259,0.001941166,0.6637293,0.0002279976,0.001378424,0.00004097424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997027,0.002152898,0.0004977492,0.00004092883,0.00001437238,0.00003884321,0.00008093458,0.0000117715,0.0001354881],"genre_scores_gemma":[0.9957117,0.002077123,0.001234749,0.00006874141,0.00002285528,0.0001780887,0.0002228792,0.000005521887,0.0004783526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009316208,"threshold_uncertainty_score":0.003333509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414484157109113,"score_gpt":0.2863728066966142,"score_spread":0.2722279651255231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}