{"id":"W2617468904","doi":"10.1128/mbio.00603-17","title":"Peptidoglycan Association of Murein Lipoprotein Is Required for KpsD-Dependent Group 2 Capsular Polysaccharide Expression and Serum Resistance in a Uropathogenic <i>Escherichia coli</i> Isolate","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Genentech; Canada Research Chairs; Government of Canada","keywords":"Peptidoglycan; Microbiology; Bacterial outer membrane; Biology; Escherichia coli; Cell envelope; Complement system; Lipoprotein; Mutant; Bacterial cell structure; Bacterial capsule; Bacteria; In vivo; Lysis; Cell wall; Biochemistry; Immunology; Virulence; Cholesterol; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008635,0.0002923323,0.0002103018,0.0001369945,0.0001210799,0.0003079688,0.0002179491,0.0002212239,0.0006758094],"category_scores_gemma":[0.0001781845,0.0001110545,0.0002452883,0.0001069892,0.0001894761,0.0001240271,0.0004087737,0.0004724273,0.0003334469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218267,"about_ca_system_score_gemma":0.000150661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260408,"about_ca_topic_score_gemma":0.001053931,"domain_scores_codex":[0.9998166,0.00003532513,0.00002067979,0.00003054402,0.00005636408,0.00004049482],"domain_scores_gemma":[0.9998216,0.00003476245,0.00006215105,0.00002240493,0.00002117951,0.00003794822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002785588,0.00001507715,0.000331845,0.00000966891,0.000001617121,0.00005585713,0.00001219403,0.00001277828,0.99928,0.00001279676,0.000009275659,0.0002309742],"study_design_scores_gemma":[0.000004936995,0.000166647,0.02189852,0.000005272241,0.00001002273,0.0005937738,0.0000837564,0.0006806949,0.9758911,0.00001674096,0.0006429207,0.000005768267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983075,0.0001062985,0.0009981055,0.00004559874,0.000005711119,0.00001255481,0.0001744325,0.00002786247,0.000321947],"genre_scores_gemma":[0.9972899,0.00007310717,0.001173802,0.00003034417,0.000003604592,0.00001361174,0.0005647634,0.00002095465,0.0008299006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260408,"threshold_uncertainty_score":0.002506137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124758010162074,"score_gpt":0.2620458855063754,"score_spread":0.2507983054047546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}